Introduction: Tissue plasminogen activator (tPA), commonly used for treatment of acute ischemic stroke, is associated with life-threatening bleeding intracranially as well as surrounding the airway.
Case Report: A 78-year-old year old male who presented with stroke symptoms and after tPA administration developed a retropharyngeal hematoma requiring intubation and surgical intervention.
Conclusion: Numerous threats to the patient’s airway can develop after tPA administration. While angioedema is the most common cause, it is important to be prepared for other causes related to hemorrhage.
","language":"eng","license":{"name":"Creative Commons Attribution 4.0","short_name":"CC BY 4.0","text":"Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.","url":"https://creativecommons.org/licenses/by/4.0"},"keywords":[{"word":"retropharyngeal hematoma"},{"word":"tissue plasminogen activator"},{"word":"stroke"},{"word":"airway"},{"word":"hemorrhage"}],"section":"Case Reports","is_remote":true,"remote_url":"https://escholarship.org/uc/item/47c010vm","frozenauthors":[{"first_name":"Christian","middle_name":"","last_name":"Provenza","name_suffix":"","institution":"University of Tennessee Health Science Center - Department of Emergency Medicine, Memphis, Tennessee","department":""},{"first_name":"Arun","middle_name":"Christian","last_name":"Habermann","name_suffix":"","institution":"University of Tennessee Health Science Center College of Medicine, Memphis, Tennessee","department":""},{"first_name":"Theron","middle_name":"","last_name":"Williams","name_suffix":"","institution":"University of Tennessee Health Science Center - Department of Emergency Medicine, Memphis, Tennessee","department":""},{"first_name":"Jeffrey","middle_name":"","last_name":"Metter","name_suffix":"","institution":"University of Tennessee Health Science Center – Department of Neurology, Memphis, Tennessee","department":""},{"first_name":"James","middle_name":"Richard","last_name":"Walker","name_suffix":"III","institution":"University of Tennessee Health Science Center – Department of Neurology, Memphis, Tennessee","department":""}],"date_submitted":"2023-08-10T04:13:39.057000Z","date_accepted":"2023-08-10T04:31:19.609000Z","date_published":"2023-08-14T16:00:00Z","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/uciem_cpcem/article/1602/galley/1137/download/"}]}