{"pk":16600,"title":"Tinnitus as a Measure of Salicylate Toxicity in the Overdose Setting","subtitle":null,"abstract":"Introduction: The development of tinnitus and/or hearing loss (THL) in patients receiving chronic salicylate therapy has been demonstrated. However, to date, little scientific data validates this relationship in the large single overdose setting.\n\n\nObjective: To correlate salicylate levels in patients with the subjective complaint of THL, following an acute salicylate overdose.\n\n\nMethods: A retrospective chart review of cases of acute salicylate toxicity and THL reported to the Illinois Poison Control Center (IPC) from 2001-2002 was performed. Data abstracted included age, gender, ingestion time, salicylate levels, and arterial blood gases.\n\n\nResults: Ninety-nine cases of THL were reviewed and analyzed with mean age of 23.7 years (SD: 10.9), 30.3% male, and 82.2% intentional overdoses. The average dose ingested was 20.0 grams (SD:20.2) and the mean time from ingestion to medical care was 12.4 hours (SD: 11.1). The mean initial ASA level was 48.3 mg/dl (SD: 16.4) with 86.9% having initial level ≥ 30mg/dl and 40.4% ≥ 50 mg/dl. 85.9% of cases presented to the hospital with their ASA level at or past peak. The mean pH was 7.45, pO2 = 108, pCO2 = 28.0, and HCO3 = 19.9.\n\n\nConclusion: In this limited study, 85.9% of patients presenting with tinnitus and/or hearing loss following a single salicylate ingestion had initial salicylate levels at or past their peak and 86.9% were in the toxic range.\n\n\n[WestJEM. 2008;9:146-149.]","language":"en","license":{"name":"none","short_name":"none","text":"","url":"http://google.com"},"keywords":[{"word":"Salicylate"},{"word":"Tinnitus"},{"word":"overdose"},{"word":"Salicylate levels"}],"section":"Article","is_remote":true,"remote_url":"https://escholarship.org/uc/item/01j749kg","frozenauthors":[{"first_name":"Scott","middle_name":"R","last_name":"Samlan","name_suffix":"","institution":"Emergency Medicine Residency Program, Resurrection Medical Center, Chicago, Illinois","department":"None"},{"first_name":"Matthew","middle_name":"T","last_name":"Jordan","name_suffix":"","institution":"Emergency Medicine Residency Program, Resurrection Medical Center, Chicago, Illinois","department":"None"},{"first_name":"Shu","middle_name":"B.","last_name":"Chan","name_suffix":"","institution":"Emergency Medicine Residency Program, Resurrection Medical Center","department":"None"},{"first_name":"Michael","middle_name":"S","last_name":"Wahl","name_suffix":"","institution":"Evanston Northwestern Healthcare, Illinois Poison Center, Chicago & Evanston, Illinois","department":"None"},{"first_name":"Rachel","middle_name":"L","last_name":"Rubin","name_suffix":"","institution":"Emergency Medicine Residency Program, Resurrection Medical Center","department":"None"}],"date_submitted":"2007-11-20T08:00:00Z","date_accepted":"2007-11-20T08:00:00Z","date_published":"2008-06-23T07:00:00Z","render_galley":null,"galleys":[{"label":"","type":"pdf","path":"https://journalpub.escholarship.org/westjem/article/16600/galley/8397/download/"}]}