{"pk":24539,"title":"Modulation of rhythmic brain circuitry alters the pattern of experience-based decision processing","subtitle":null,"abstract":"Understanding and modulating cognitive aspects of decision-making and reinforcement learning are crucial for addressing neuropsychiatric problems like substance use disorders (SUD). We developed a non-invasive stimulation method to modulate theta phase synchronization between the medial prefrontal cortex and right lateral prefrontal cortex. Our EEG-informed modulation led to bidirectional changes in learning-based decision-making, including error-related components and brain signatures. In fact, by combining HD-tACS with mathematical modeling, we revealed that in-phase/antiphase HD-tACS over the mPFC and rPFC significantly altered (synchronized/desynchronized) theta phase coupling between these regions, influencing decision accuracy (improved/impaired), and neurocomputational parameters of learning-based decision-making. Additionally, this modulation rescued/disrupted the causal link between brain error monitoring and cognitive control systems in healthy/SUD participants, and reshaped punishment-guided decision and learning components. We concluded theta rhythms in the mPFC and mPFC-rPFC coupling play a unifying causal role in regulating choice, learning, and behavioral adaptation in both healthy and patient populations.","language":"eng","license":{"name":"","short_name":"","text":null,"url":""},"keywords":[{"word":"Cognitive Neuroscience; Learning; Brain Stimulation; Computational Modeling; Electroencephalography (EEG)"}],"section":"Abstracts","is_remote":true,"remote_url":"https://escholarship.org/uc/item/1b78f317","frozenauthors":[{"first_name":"sadegh","middle_name":"","last_name":"Ghaderi","name_suffix":"","institution":"Institute of Cognitive and Brain Sciences Cognitive modeling","department":""},{"first_name":"Mohammad","middle_name":"","last_name":"Hemami","name_suffix":"","institution":"Institute of Cognitive and Brain Sciences","department":""},{"first_name":"Jamal","middle_name":"","last_name":"Amani Rad","name_suffix":"","institution":"Shahid Beheshti University","department":""},{"first_name":"Reza","middle_name":"","last_name":"khosrowabadi","name_suffix":"","institution":"Institute of Cognitive and Brain Sciences","department":""}],"date_submitted":null,"date_accepted":null,"date_published":"2024-01-01T18:00:00Z","render_galley":{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/24539/galley/21385/download/"},"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/24539/galley/14136/download/"},{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/24539/galley/21385/download/"}]}