{"pk":25662,"title":"Influence of Excitation/Inhibition Imbalance on Local Processing Bias in\nAutism Spectrum Disorder","subtitle":null,"abstract":"People with autism spectrum disorder (ASD) tend to detect lo-\ncal patterns of visual stimuli more quickly than global patterns,\nwhich is opposite to the behavior of typically developing peo-\nple. We hypothesized that the imbalance between excitation\nand inhibition neurons in the visual cortex causes the local pro-\ncessing bias observed in ASD. Stronger inhibitory connections\ncould diminish the neural activities and thus prevent global fea-\nture integration, whereas properly balanced connections would\nenable the cortex to detect features of any size. We verified\nour hypothesis by employing a computational neural network\ncalled a neocognitron. Our experimental results demonstrated\nthat the network with stronger inhibitory connections exhib-\nited a local processing bias, whereas the network with properly\nadjusted connections showed a moderate global bias. More-\nover, the networks with extremely strong or weak inhibitions\nrevealed no perception bias. These results suggest that an ex-\ncitation/inhibition imbalance causes multiple types of atypical\nperception in ASD.","language":"eng","license":{"name":"","short_name":"","text":null,"url":""},"keywords":[{"word":"autism spectrum disorder; local processing bias;\nexcitation/inhibition balance; neocognitron"}],"section":"Papers","is_remote":true,"remote_url":"https://escholarship.org/uc/item/0tj1p2gb","frozenauthors":[{"first_name":"Yukie","middle_name":"","last_name":"Nagai","name_suffix":"","institution":"Osaka University","department":""},{"first_name":"Takakazu","middle_name":"","last_name":"Moriwaki","name_suffix":"","institution":"Osaka University","department":""},{"first_name":"Minoru","middle_name":"","last_name":"Asada","name_suffix":"","institution":"Osaka University","department":""}],"date_submitted":null,"date_accepted":null,"date_published":"2015-01-01T10:00:00-08:00","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/25662/galley/15286/download/"}]}