{"pk":26848,"title":"A Cognitive-Pharmacokinetic Computational Model of the Effect of Toluene onPerformance","subtitle":null,"abstract":"We developed a cognitive-pharmacokinetic computational(CPC) model to understand how pharmacoactive substances,such as caffeine and toluene, modulate cognition. In this in-tegrated model, dynamic physiological mechanisms are sim-ulated to predict concentrations of the solvent toluene in thebrain, which modulates specific cognitive systems in a dose-response fashion over multiple hours. We used our CPC modelto reanalyze the results from prior research that documented anincrease in reaction time following exposure to toluene in sev-eral laboratory tasks with no change in accuracy. Our analysisprovides tentative evidence that toluene affects motor execu-tion, rather than attention or declarative memory.","language":"eng","license":{"name":"","short_name":"","text":null,"url":""},"keywords":[{"word":"ACT-R; Toluene; Pharmacokinetic; Computa-tional Models"}],"section":"Talks: Papers","is_remote":true,"remote_url":"https://escholarship.org/uc/item/1mh7619k","frozenauthors":[{"first_name":"Christopher","middle_name":"R.","last_name":"Fisher","name_suffix":"","institution":"Air Force Research Laboratory, Wright-Patterson Air Force Base","department":""},{"first_name":"Christopher","middle_name":"","last_name":"Myers","name_suffix":"","institution":"Air Force Research Laboratory, Wright-Patterson Air Force Base","department":""},{"first_name":"Reem","middle_name":"","last_name":"Hassan","name_suffix":"","institution":"Air Force Research Laboratory, Wright-Patterson Air Force Base","department":""},{"first_name":"Christopher","middle_name":"","last_name":"Stevens","name_suffix":"","institution":"Air Force Research Laboratory, Wright-Patterson Air Force Base","department":""},{"first_name":"C. Eric","middle_name":"","last_name":"Hack","name_suffix":"","institution":"Air Force Research Laboratory, Wright-Patterson Air Force Base","department":""},{"first_name":"Jeffery","middle_name":"","last_name":"Gearhart","name_suffix":"","institution":"Air Force Research Laboratory, Wright-Patterson Air Force Base","department":""},{"first_name":"Glenn","middle_name":"","last_name":"Gunzelmann","name_suffix":"","institution":"Air Force Research Laboratory, Wright-Patterson Air Force Base","department":""}],"date_submitted":null,"date_accepted":null,"date_published":"2017-01-01T18:00:00Z","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/26848/galley/16484/download/"}]}