{"pk":27869,"title":"Dorsal Premotor Cortex and Conditional Rule Resolution: A High-Frequency TMS Investigation","subtitle":null,"abstract":"Behavior that is contingent on conditional rules necessitatesan abstraction away from concrete stimulus-response identi-ties in order to form a rule template, but also a subsequenttransformation of representation back into sensorimotor for-mat in order to produce concrete behavior. Evidence suggeststhat dorsal premotor cortex (PMd) is well-positioned to me-diate such an operation. We utilized repetitive transcranialmagnetic stimulation, a non-invasive manner of perturbing thefunctioning of targeted cortical regions, to investigate the roleof dorsal premotor cortex during performance of a Rapid In-structed Task Learning paradigm. The task required partici-pants to form conditional associations between stimuli and re-sponses carrying varying levels of abstraction. Selective inter-ference of response times to stimuli presentation was observedonly when the task necessitated the participants to resolve aconditional response referring to an internally-produced repre-sentation of a rule element with relatively abstracted quality.We conclude that PMd specifically supports conditional rulebehavior through transformation of abstract representations toconcrete response, when the conditional rule necessary to re-solve includes abstract, internally-produced identities.","language":"eng","license":{"name":"","short_name":"","text":null,"url":""},"keywords":[{"word":"Prefrontal Cortex"},{"word":"Premotor cortex"},{"word":"Transcranial magnetic stimulation"},{"word":"Stimulus-Response associations"},{"word":"Abstract rule representation"}],"section":"Publication-based-Talks","is_remote":true,"remote_url":"https://escholarship.org/uc/item/42g5w7w5","frozenauthors":[{"first_name":"Patrick","middle_name":"J","last_name":"Rice","name_suffix":"","institution":"University of Washington (UW)","department":""},{"first_name":"Andrea","middle_name":"","last_name":"Stocco","name_suffix":"","institution":"UW","department":""}],"date_submitted":null,"date_accepted":null,"date_published":"2018-01-01T18:00:00Z","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/27869/galley/17507/download/"}]}