{"pk":28989,"title":"The role of AMPA receptor exchange in systems memory reconsolidation: Acomputational model","subtitle":null,"abstract":"In the mammalian brain, a newly acquired memory depends on the hippocampus for maintenance and recall, but over timethe neocortex takes over these functions, rendering the memory hippocampus-independent. The process responsible forthis transformation is called systems memory consolidation. Interestingly, retrieval of a well-consolidated memory cantrigger a temporary return to a hippocampus-dependent state, a phenomenon known as systems memory reconsolidation.The neural mechanisms underlying systems memory consolidation and reconsolidation are not well understood. Here,we propose a neural model based on well-documented mechanisms of synaptic plasticity and stability and describe acomputational implementation that demonstrates the models ability to account for a range of findings from the systemsconsolidation and reconsolidation literature. Based on the computational model, we derive a number of predictions andsuggest experiments that may put them to the test.","language":"eng","license":{"name":"","short_name":"","text":null,"url":""},"keywords":[],"section":"Poster Presentations with Abstracts","is_remote":true,"remote_url":"https://escholarship.org/uc/item/00s7m48t","frozenauthors":[{"first_name":"Peter","middle_name":"","last_name":"Helfer","name_suffix":"","institution":"McGill University","department":""},{"first_name":"Thomas","middle_name":"","last_name":"Shultz","name_suffix":"","institution":"McGill University","department":""}],"date_submitted":null,"date_accepted":null,"date_published":"2019-01-01T18:00:00Z","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/28989/galley/18860/download/"}]}