{"pk":30037,"title":"Applying the Common Model of Cognition to Resting-State fMRI Leads to theIdentification of Abnormal Functional Connectivity in Parkinson’s Disease","subtitle":null,"abstract":"A complete understanding of cognitive function in humansmust incorporate a model of interactions between networkedbrain regions. Alterations to these network interactions under-lie cognitive impairment in many neurodegenerative diseases,providing an important physiological link between brain struc-ture and cognitive function. Cognitive architectures have of-ten been used to explain how healthy brains function, typi-cally using task-based activity. However, this description isincomplete. Most systems-level brain activity is spontaneous,or intrinsic, and occurs whether or not a subject is performinga task. Here, we provide evidence that the Common Modelof Cognition, a consensus model derived from an analysis ofexisting cognitive architectures, can (a) be generalized to ac-count for brain activity at rest, rather than during tasks, and (b)correctly identify differences in basal ganglia connectivity inParkinson’s Disease.","language":"eng","license":{"name":"","short_name":"","text":null,"url":""},"keywords":[{"word":"Common Model of Cognition; Resting-statefMRI; Parkinson’s Disease; Dynamic Causal Modeling"}],"section":"Poster Session 3","is_remote":true,"remote_url":"https://escholarship.org/uc/item/3404d4c0","frozenauthors":[{"first_name":"Micah","middle_name":"","last_name":"Ketola","name_suffix":"","institution":"University of Washington","department":""},{"first_name":"Shelby","middle_name":"","last_name":"Thompson","name_suffix":"","institution":"Spelman College","department":""},{"first_name":"Tara","middle_name":"","last_name":"Madhyastha","name_suffix":"","institution":"Amazon Web Services","department":""},{"first_name":"Thomas","middle_name":"J.","last_name":"Grabowski","name_suffix":"","institution":"University of Washington","department":""},{"first_name":"Andrea","middle_name":"","last_name":"Stocco","name_suffix":"","institution":"University of Washington","department":""}],"date_submitted":null,"date_accepted":null,"date_published":"2020-01-01T18:00:00Z","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/30037/galley/19891/download/"}]}