Introduction: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis typically affecting dermal capillaries and venules. The condition is often idiopathic but can be associated with infections, neoplasms, autoimmune disorders, and certain drugs.
\nCase Report: A 91-year-old female with past medical history of Alzheimer dementia and hypertension, being treated for lower extremity cellulitis, presented to the emergency department for an allergic reaction. Trimethoprim/sulfamethoxazole (TMP/SMX) had been initiated six days earlier. The patient was noted to have normal vital signs. Palpable purpura was discovered on the lower back, buttocks, lower extremities, ankles, and feet. Laboratory studies were within normal limits. Given the clinical presentation, physical exam findings, and normal eosinophil count, the diagnosis of LCV secondary to TMP/SMX was made.
\nConclusion: Most cases of LCV are limited to cutaneous symptoms and self-resolve with supportive care.
","language":"eng","license":{"name":"Creative Commons Attribution 4.0","short_name":"CC BY 4.0","text":"Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.","url":"https://creativecommons.org/licenses/by/4.0"},"keywords":[{"word":"Leukocytoclastic vasculitis (LCV)"},{"word":"trimethoprim/sulfamethoxazole (TMP/SMX)"},{"word":"drug reaction"},{"word":"Immunoglobulin A vasculitis"}],"section":"Case Reports","is_remote":true,"remote_url":"https://escholarship.org/uc/item/8j68w5fg","frozenauthors":[{"first_name":"Ambika","middle_name":"","last_name":"Shivarajpur","name_suffix":"","institution":"Memorial Healthcare System, Department of Emergency Medicine, Hollywood, Florida","department":""},{"first_name":"Simon","middle_name":"","last_name":"Londono","name_suffix":"","institution":"Memorial Healthcare System, Department of Emergency Medicine, Hollywood, Florida","department":""},{"first_name":"Justin","middle_name":"","last_name":"Shaw","name_suffix":"","institution":"Florida International University, Herbert Wertheim College of Medicine, Miami, Florida","department":""},{"first_name":"Christopher","middle_name":"","last_name":"Boccio","name_suffix":"","institution":"NYC Health + Hospitals/Bellevue New York, Department of Pharmacy, New York, New York","department":""},{"first_name":"Leon","middle_name":"","last_name":"Melnitsky","name_suffix":"","institution":"Memorial Healthcare System, Department of Emergency Medicine, Hollywood, Florida","department":""},{"first_name":"Jheanelle","middle_name":"","last_name":"McKay","name_suffix":"","institution":"Joe DiMaggio Children’s Hospital, Department of Pediatric Emergency Medicine, Hollywood, Florida","department":""},{"first_name":"Brian","middle_name":"","last_name":"Kohen","name_suffix":"","institution":"Memorial Healthcare System, Department of Emergency Medicine, Hollywood, Florida","department":""},{"first_name":"Eric","middle_name":"","last_name":"Boccio","name_suffix":"","institution":"Memorial Healthcare System, Department of Emergency Medicine, Hollywood, Florida","department":""}],"date_submitted":"2024-07-19T05:16:19.550000+02:00","date_accepted":"2024-09-29T16:27:38.684000+02:00","date_published":"2025-01-06T18:53:00+01:00","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/uciem_cpcem/article/31056/galley/31531/download/"}]}