Introduction: Diphenhydramine overdose is a growing concern, particularly among adolescents influenced by online challenges. Traditionally managed with supportive care and sodium bicarbonate, severe cases may exhibit refractory symptoms due to sodium channel toxicity, necessitating alternative treatments.
\nCase Report: A 28-year-old male with a history of anxiety and depression presented to the emergency department unresponsive, next to an empty bottle of Benadryl and wine bottles. Vital signs indicated hypotension and hypoxia. The patient was intubated and administered vasopressors. Initial ECG showed a widened QRS complex and terminal R wave in lead aVR, suggesting sodium channel blockade. Treatment with multiple boluses of sodium bicarbonate was ineffective. Lidocaine (95 mg IV) was administered, resulting in improved ECG findings and patient stabilization. Subsequent care focused on supportive measures and treatment for aspiration pneumonia. The patient was extubated on day 2 and discharged on day 7 to a behavioral health facility.
\nConclusion: This case underscores the effectiveness of lidocaine as a secondary treatment for diphenhydramine-induced sodium channel toxicity when standard sodium bicarbonate therapy fails. Lidocaine's ability to restore myocardial conduction illustrates its potential as a critical intervention in toxicological emergencies.
","language":"eng","license":{"name":"Creative Commons Attribution 4.0","short_name":"CC BY 4.0","text":"Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.","url":"https://creativecommons.org/licenses/by/4.0"},"keywords":[{"word":"Diphenhydramine overdose"},{"word":"Sodium channel toxicity"},{"word":"Lidocaine"},{"word":"case report"},{"word":"Sodium bicarbonate resistance"}],"section":"Case Reports","is_remote":true,"remote_url":"https://escholarship.org/uc/item/2b49595b","frozenauthors":[{"first_name":"Kassem","middle_name":"Michael","last_name":"Makki","name_suffix":"","institution":"New York Presbyterian-Brooklyn Methodist Hospital, Division of Emergency Medicine","department":""},{"first_name":"David","middle_name":"","last_name":"Mandil","name_suffix":"","institution":"New York Presbyterian-Brooklyn Methodist Hospital, Division of Emergency Medicine","department":""},{"first_name":"Roger","middle_name":"","last_name":"Hopson","name_suffix":"","institution":"New York Presbyterian-Brooklyn Methodist Hospital, Division of Internal Medicine, Pulmonary and Critical Care","department":""},{"first_name":"Maxim","middle_name":"","last_name":"Kashin","name_suffix":"","institution":"New York Presbyterian-Brooklyn Methodist Hospital, Division of Internal Medicine, Pulmonary and Critical Care","department":""},{"first_name":"Roger","middle_name":"","last_name":"Rothenberg","name_suffix":"","institution":"New York University Langone Health, Division of Toxicology","department":""},{"first_name":"Noah","middle_name":"","last_name":"Reisman","name_suffix":"","institution":"New York Presbyterian-Brooklyn Methodist Hospital, Division of Internal Medicine, Pulmonary and Critical Care","department":""},{"first_name":"Brenna","middle_name":"","last_name":"Farmer","name_suffix":"","institution":"New York Presbyterian-Brooklyn Methodist Hospital, Division of Emergency Medicine","department":""}],"date_submitted":"2024-12-14T16:41:10.443000Z","date_accepted":"2025-02-28T17:00:33.815000Z","date_published":"2025-04-30T07:28:00Z","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/uciem_cpcem/article/41491/galley/35742/download/"}]}