{"pk":49740,"title":"Representational similarity analysis between ADHD and SCZ based on functional brain network","subtitle":null,"abstract":"Attention deficit hyperactivity disorder (ADHD) and schizophrenia (SCZ) have complex neural mechanisms. This study used fMRI data from resting state and 2-back working memory tasks to analyze the abnormal brain network characteristics of the two. The results showed that ADHD patients had dispersed functional connections under task conditions, and increased node degrees in the prefrontal cortex, insula, anterior cingulate gyrus, and cerebellum, indicating compensatory network reorganization. SCZ patients showed abnormal connections between the default mode network and the limbic cortex, and weakened coupling between the parietal lobe and the attention network, reflecting cognitive integration and emotion regulation defects. Through representational similarity analysis (RSA), it was found that the two diseases had shared abnormal connections in the prefrontal cortex, middle temporal gyrus, and hippocampus, which may be related to working memory regulation disorders. These findings provide potential biomarkers for targeted intervention.","language":"eng","license":{"name":"","short_name":"","text":null,"url":""},"keywords":[{"word":"Biology; Cognitive Neuroscience; Development; Memory; fMRI"}],"section":"Papers with Poster Presentation","is_remote":true,"remote_url":"https://escholarship.org/uc/item/78z623r1","frozenauthors":[{"first_name":"Binsong","middle_name":"","last_name":"Tang","name_suffix":"","institution":"Chongqing University of Posts and Telecommunications","department":""},{"first_name":"Yu","middle_name":"","last_name":"Xiong","name_suffix":"","institution":"Chong University of Posts and Telecommunications","department":""},{"first_name":"Yin","middle_name":"","last_name":"Tian","name_suffix":"","institution":"Chongqing University of Posts and Telecommunications","department":""}],"date_submitted":null,"date_accepted":null,"date_published":"2025-01-01T18:00:00Z","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/49740/galley/37702/download/"}]}