{"pk":50474,"title":"Age-related changes in cognitive flexibility: fMRI meta-analysis","subtitle":null,"abstract":"<p>To examine neural mechanisms underlying cognitive flexibility changes with ageing, we synthesized findings from 87 fMRI studies, comprising 120 experiments with 2308 adult participants distributed across young, middle-age, and older groups. Our meta-analysis was focused on rule-retrieval and rule-discovery processes, assessed with Task-Switching Paradigm and Wisconsin Card Sorting Test, respectively. Activation Likelihood Estimation analyses revealed age-related decreases in brain activation related to general switching ability, particularly in posterior regions, alongside an anterior shift in older adults, consistent with the Posterior-Anterior Shift in Aging (PASA) model. Rule-retrieval tasks consistently engaged left-lateralized frontoparietal regions across all age groups, with middle-age adults additionally recruiting the right cerebellum and medial-frontal gyrus. For rule-discovery tasks, age-related decline was observed in bilateral frontoparietal regions, while older adults also showed unique activation in the left inferior-frontal gyrus. These findings highlight differential ageing trajectories for rule retrieval and rule discovery, potentially reflecting compensatory neural mechanisms and dedifferentiation processes.</p>","language":"eng","license":{"name":"","short_name":"","text":null,"url":""},"keywords":[{"word":"Cognitive Neuroscience; Neuroscience; Psychology; Cognitive development; Development; Other; fMRI"}],"section":"Member Abstracts with Poster Presentation","is_remote":true,"remote_url":"https://escholarship.org/uc/item/0zn5r8z3","frozenauthors":[{"first_name":"Zhanna","middle_name":"","last_name":"Chuikova","name_suffix":"","institution":"HSE University","department":""},{"first_name":"Andrei","middle_name":"","last_name":"Faber","name_suffix":"","institution":"HSE University","department":""},{"first_name":"Andrei","middle_name":"","last_name":"Filatov","name_suffix":"","institution":"HSE University","department":""},{"first_name":"Andriy","middle_name":"","last_name":"Myachykov","name_suffix":"","institution":"University of Macau","department":""},{"first_name":"Yury","middle_name":"","last_name":"Shtyrov","name_suffix":"","institution":"Aarhus University","department":""},{"first_name":"Marie","middle_name":"","last_name":"Arsalidou","name_suffix":"","institution":"York University","department":""}],"date_submitted":null,"date_accepted":null,"date_published":"2025-01-01T18:00:00Z","render_galley":null,"galleys":[{"label":"PDF","type":"pdf","path":"https://journalpub.escholarship.org/cognitivesciencesociety/article/50474/galley/38436/download/"}]}