{"pk":5315,"title":"Conditioned Aversion for a Cocaine-paired Cue Predicts Cocaine Seeking and Taking in Rats","subtitle":null,"abstract":"Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocaine-paired taste cue, and greater conditioned aversive TR in well-trained rats predicts greater drug-taking. Here, we used a between-groups design and tracked the development of this conditioned aversive TR behavior on a trial by trial basis in an effort to determine when the change in behavior occurs and at what point individual differences in cue reactivity become predictive of cocaine-seeking and cocaine-taking. The results demonstrate that conditioned aversive TR to a cocaine-predictive flavor cue appears very early in training (i.e., following as few as 1 – 2 taste-drug pairings), stabilizes quickly, and becomes predictive of “terminal” self-administration within 3 – 4 trials. Indeed, rats exhibiting high conditioned aversive TR to the cocaine-paired cue also exhibited greater goal-directed behavior, were faster to take drug, self-administered more cocaine, and exhibited greater seeking during periods of drug non-availability. High conditioned aversive TR, then, develops quickly and is indicative of a greater motivation for drug.","language":"en","license":{"name":"Creative Commons Attribution 4.0","short_name":"CC BY 4.0","text":"Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.","url":"https://creativecommons.org/licenses/by/4.0"},"keywords":[{"word":"conditioned aversion"},{"word":"Cocaine"},{"word":"reward comparison"},{"word":"anticipatory contrast"}],"section":"Special Issue: Revisiting The Legacy of Stan Kuczaj","is_remote":true,"remote_url":"https://escholarship.org/uc/item/1dc097vq","frozenauthors":[{"first_name":"Elizabeth","middle_name":"M.","last_name":"Colechio","name_suffix":"","institution":"","department":"None"},{"first_name":"Patricia","middle_name":"Sue","last_name":"Grigson","name_suffix":"","institution":"Other","department":"None"}],"date_submitted":"2014-06-17T04:12:18Z","date_accepted":"2014-06-17T04:12:18Z","date_published":"2014-08-24T23:07:04Z","render_galley":null,"galleys":[{"label":"","type":"","path":"https://journalpub.escholarship.org/uclapsych_ijcp/article/5315/galley/3182/download/"}]}