{"pk":609,"title":"Emergent Treatment of Neuroleptic Malignant Syndrome Induced by Antipsychotic Monotherapy Using Dantrolene","subtitle":null,"abstract":"Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication resulting from neuroleptic drug therapy. Presentation of NMS can vary, and diagnosis relies primarily upon medical history and symptomatology. Due to the potential delay in diagnosis, emergency physicians should remain vigilant in recognizing the symptoms of NMS and be prepared to initiate immediate treatment following diagnosis. Dantrolene, which has been used for spasticity and malignant hyperthermia, has been reported as a potential treatment for NMS and led to off-label use for NMS. We report two cases of NMS induced by antipsychotic monotherapy for which dantrolene was administered.","language":"en","license":{"name":"Creative Commons Attribution 4.0","short_name":"CC BY 4.0","text":"Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.","url":"https://creativecommons.org/licenses/by/4.0"},"keywords":[],"section":"Case Reports","is_remote":true,"remote_url":"https://escholarship.org/uc/item/74v0t38z","frozenauthors":[{"first_name":"Vivian","middle_name":"","last_name":"Ngo","name_suffix":"","institution":"Arrowhead Regional Medical Center, Department of Family Medicine, Colton, California","department":"None"},{"first_name":"Alfredo","middle_name":"","last_name":"Guerrero","name_suffix":"","institution":"Arrowhead Regional Medical Center, Department of Emergency Medicine, Colton, California","department":"None"},{"first_name":"David","middle_name":"","last_name":"Lanum","name_suffix":"","institution":"Arrowhead Regional Medical Center, Department of Family Medicine, Colton, California; California University of Sciences and Medicine, Colton, California","department":"None"},{"first_name":"Michelle","middle_name":"","last_name":"Burgett-Moreno","name_suffix":"","institution":"Arrowhead Regional Medical Center, Department of Anesthesia, Colton, California","department":"None"},{"first_name":"Gregory","middle_name":"","last_name":"Fenati","name_suffix":"","institution":"Arrowhead Regional Medical Center, Department of Emergency Medicine, Colton, California; California University of Sciences and Medicine, Department of Emergency Medicine, Colton, California","department":"None"},{"first_name":"Steven","middle_name":"","last_name":"Barr","name_suffix":"","institution":"Arrowhead Regional Medical Center, Department of Anesthesia, Colton, California","department":"None"},{"first_name":"Michael","middle_name":"M.","last_name":"Neeki","name_suffix":"","institution":"Arrowhead Regional Medical Center, Department of Emergency Medicine, Colton, California; California University of Sciences and Medicine, Colton, California","department":"None"}],"date_submitted":"2018-11-16T00:58:44+01:00","date_accepted":"2018-11-16T00:58:44+01:00","date_published":"2019-01-04T18:31:15+01:00","render_galley":null,"galleys":[{"label":"","type":"","path":"https://journalpub.escholarship.org/uciem_cpcem/article/609/galley/369/download/"}]}