{"pk":7818,"title":"Sedative Dosing Of Propofol For Treatment Of Migraine Headache In The Emergency Department: A Case Series","subtitle":null,"abstract":"Introduction: Migraine headaches requiring an emergency department visit due to failed outpatient rescue therapy present a significant challenge in terms of length of stay (LOS) and financial costs. Propofol therapy may be effective at pain reduction and reduce that length of stay given its pharmacokinetic properties as a short acting intravenous sedative anesthetic and pharmacodynamics on GABA mediated chloride flux.Methods: Case series of 4 patients presenting to an urban academic medical center with migraine headache failing outpatient therapy. Each patient was given a sedation dose (1 mg/kg) of propofol under standard procedural sedation precautions.Results: Each of the 4 patients experienced dramatic reductions or complete resolution of headache severity. LOS for 3 of the 4 patients was 50% less than the average LOS for patients with similar chief complaints to our emergency department. 1 patient required further treatment with standard therapy but had a significant reduction in pain and a shorter LOS. There were no episodes of hypotension, hypoxia, or apnea during the sedations.Conclusion: In this small case series, sedation dose propofol appears to be effective and safe for the treatment of refractory migraines, and may result in a reduced LOS. [West J Emerg Med. 2013;14(6):646-649.]","language":"en","license":{"name":"Creative Commons Attribution-NonCommercial  4.0","short_name":"CC BY-NC 4.0","text":"Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNonCommercial — You may not use the material for commercial purposes.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.","url":"https://creativecommons.org/licenses/by-nc/4.0"},"keywords":[{"word":"Key Words: Migraine, Propofol"},{"word":"Emergency Medicine"}],"section":"Diagnostic Acumen","is_remote":true,"remote_url":"https://escholarship.org/uc/item/47s3x00b","frozenauthors":[{"first_name":"Jarrod","middle_name":"","last_name":"Mosier","name_suffix":"","institution":"University of Arizona, Departments of Emergency Medicine and Internal Medicine, Tucson, Arizona","department":"None"},{"first_name":"Grant","middle_name":"","last_name":"Roper","name_suffix":"","institution":"University of Arizona, Department of Emergency Medicine, Tucson, Arizona","department":"None"},{"first_name":"Daniel","middle_name":"","last_name":"Hays, PharmD","name_suffix":"","institution":"University of Arizona, Department of Emergency Medicine, Tucson, Arizona","department":"None"},{"first_name":"John","middle_name":"","last_name":"Guisto","name_suffix":"","institution":"University of Arizona, Department of Emergency Medicine, Tucson, Arizona","department":"None"}],"date_submitted":"2013-05-02T22:36:30Z","date_accepted":"2013-05-02T22:36:30Z","date_published":"2013-11-05T08:00:00Z","render_galley":null,"galleys":[{"label":"","type":"pdf","path":"https://journalpub.escholarship.org/westjem/article/7818/galley/4557/download/"}]}