{"pk":912,"title":"Immunocompromised Child on Infliximab: A Case Report of Listeria monocytogenes Meningitis","subtitle":null,"abstract":"Introduction:\n Patients with naturally occurring, impaired cell-mediated immunity secondary to age and pregnancy are known to be at risk of developing severe and invasive Listeria monocytogenes infections. Immunosuppressant medications, particularly infliximab, are also known to increase this risk.\nCase Report:\n We present the case of a seven-year-old female on infliximab who was diagnosed with culture positive L. monocytogenes meningitis after a negative cerebral spinal fluid polymerase chain reaction (PCR).\nConclusion:\n Patients receiving infliximab who display signs of central nervous system infection should be suspected to have L. monocytogenes as an infecting agent, and empiric addition of ampicillin to their antibiotic regimen should be considered, with substitution of trimethoprim-sulfamethoxazole in cases of penicillin allergy, regardless of initial PCR results.","language":"en","license":{"name":"Creative Commons Attribution 4.0","short_name":"CC BY 4.0","text":"Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.","url":"https://creativecommons.org/licenses/by/4.0"},"keywords":[{"word":"listeria monocytogenes"},{"word":"infliximab"}],"section":"Case Reports","is_remote":true,"remote_url":"https://escholarship.org/uc/item/90w3z8m3","frozenauthors":[{"first_name":"Camille","middle_name":"","last_name":"Halfman","name_suffix":"","institution":"SUNY Upstate Medical University, Department of Emergency Medicine, Syracuse, New York","department":"None"},{"first_name":"Luke","middle_name":"","last_name":"Slate","name_suffix":"","institution":"SUNY Upstate Medical University, Department of Emergency Medicine, Syracuse, New York","department":"None"},{"first_name":"Julienne","middle_name":"","last_name":"Yamamoto","name_suffix":"","institution":"SUNY Upstate Medical University, Department of Emergency Medicine, Syracuse, New York","department":"None"},{"first_name":"Samantha","middle_name":"","last_name":"Jones","name_suffix":"","institution":"SUNY Upstate Medical University, Department of Emergency Medicine, Syracuse, New York","department":"None"}],"date_submitted":"2020-09-10T04:02:09+02:00","date_accepted":"2020-09-10T04:02:09+02:00","date_published":"2020-09-10T04:02:46+02:00","render_galley":null,"galleys":[{"label":"","type":"","path":"https://journalpub.escholarship.org/uciem_cpcem/article/912/galley/660/download/"}]}