Article Instance

HTTP 200 OK
Allow: GET
Content-Type: application/json
Vary: Accept

{
    "pk": 1067,
    "title": "Serotonin Syndrome Triggered by Increasing the Dose of Quetiapine",
    "subtitle": null,
    "abstract": "Case presentation:\n An 85-year-old woman with a history of depression treated with polypharmacy including selective serotonin reuptake inhibitor presented to the emergency department with head, and upper and lower limb tremors four hours after increasing the dose of quetiapine from 12.5 milligrams (mg) per day to 25 mg/day. She was diagnosed with serotonin syndrome (SS), and all medications except clotiazepam were discontinued. The symptoms subsided within 48 hours.\nDiscussion:\n The use of atypical antipsychotics alone seldom increases the risk of SS. However, combining atypical antipsychotics with serotonergic agents increases the risk of SS because the activity of serotonin receptor subtype 1A is relatively enhanced. This report suggests that physicians should be aware that even a small increase in quetiapine could pose a risk of developing SS.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "serotonin syndrome"
        },
        {
            "word": "quetiapine"
        },
        {
            "word": "tremor"
        },
        {
            "word": "neuroleptic malignant syndrome"
        }
    ],
    "section": "Images in Emergency Medicine",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/0m32v39j",
    "frozenauthors": [
        {
            "first_name": "Yayoi",
            "middle_name": "",
            "last_name": "Miyamatsu",
            "name_suffix": "",
            "institution": "Nabari City Hospital, Department of Internal Medicine, Nabari, Japan",
            "department": "None"
        },
        {
            "first_name": "Ryutaro",
            "middle_name": "",
            "last_name": "Tanizaki",
            "name_suffix": "",
            "institution": "Mie University School of Medicine, Department of Community Medicine, Nabari, Japan",
            "department": "None"
        }
    ],
    "date_submitted": "2021-08-06T00:52:44Z",
    "date_accepted": "2021-08-06T00:52:44Z",
    "date_published": "2021-08-06T00:55:35Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uciem_cpcem/article/1067/galley/809/download/"
        }
    ]
}