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{
    "pk": 10843,
    "title": "Sex as a Biological Variable in Emergency Medicine Research and Clinical Practice: A Brief Narrative Review",
    "subtitle": null,
    "abstract": "The National Institutes of Health recently highlighted the significant role of sex as a biologicalvariable (SABV) in research design, outcome and reproducibility, mandating that this variable beaccounted for in all its funded research studies. This move has resulted in a rapidly increasing bodyof literature on SABV with important implications for changing the clinical practice of emergencymedicine (EM). Translation of this new knowledge to the bedside requires an understanding ofhow sex-based research will ultimately impact patient care. We use three case-based scenarios inacute myocardial infarction, acute ischemic stroke and important considerations in pharmacologictherapy administration to highlight available data on SABV in evidence-based research to providethe EM community with an important foundation for future integration of patient sex in the delivery ofemergency care as gaps in research are filled.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "sex and gender, sex as a biological variable, emergency medicine, cardiovascular, neurovascular, stroke, toxicology, pharmacology"
        }
    ],
    "section": "Population Health Research Design",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/06t1n9d7",
    "frozenauthors": [
        {
            "first_name": "Alyson",
            "middle_name": "J.",
            "last_name": "McGregor",
            "name_suffix": "",
            "institution": "Warren Alpert Medical School of Brown University, Department of Emergency\nMedicine, Division of Sex and Gender in Emergency Medicine, Providence, Rhode Island",
            "department": "None"
        },
        {
            "first_name": "Gillian",
            "middle_name": "A.",
            "last_name": "Beauchamp",
            "name_suffix": "",
            "institution": "Oregon Health & Science University, Department of Emergency Medicine, Portland,\nOregon",
            "department": "None"
        },
        {
            "first_name": "Charles",
            "middle_name": "R.",
            "last_name": "Wira",
            "name_suffix": "",
            "institution": "Yale University School of Medicine, Department of Emergency Medicine, New Haven, Connecticut",
            "department": "None"
        },
        {
            "first_name": "Sarah",
            "middle_name": "M.",
            "last_name": "Perman",
            "name_suffix": "",
            "institution": "University of Colorado, School of Medicine, Department of Emergency Medicine, Aurora,\nColorado",
            "department": "None"
        },
        {
            "first_name": "Basmah",
            "middle_name": "",
            "last_name": "Safdar",
            "name_suffix": "",
            "institution": "Yale University School of Medicine, Department of Emergency Medicine, New Haven, Connecticut",
            "department": "None"
        }
    ],
    "date_submitted": "2017-05-29T14:28:12Z",
    "date_accepted": "2017-05-29T14:28:12Z",
    "date_published": "2017-10-06T07:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/10843/galley/5895/download/"
        }
    ]
}