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{
    "pk": 11249,
    "title": "Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department",
    "subtitle": null,
    "abstract": "Introduction:\n Our objective was to describe dosing, duration, and pre- and post-infusion analgesic administration of continuous intravenous sub-dissociative dose ketamine (SDK) infusion for managing a variety of painful conditions in the emergency department (ED). \nMethods:\n We conducted a retrospective chart review of patients aged 18 and older presenting to the ED with acute and chronic painful conditions who received continuous SDK infusion in the ED for a period over six years (2010-2016). Primary data analyses included dosing and duration of infusion, rates of pre- and post-infusion analgesic administration, and final diagnoses. Secondary data included pre- and post-infusion pain scores and rates of side effects.\nResults:\n A total of 104 patients were enrolled in the study. Average dosing of SDK infusion was 11.26 mg/hr, and the mean duration of infusion was 135.87 minutes. There was a 38% increase in patients not requiring post-infusion analgesia. The average decrease in pain score was 5.04. There were 12 reported adverse effects, with nausea being the most prevalent.\nConclusion:\n Continuous intravenous SDK infusion has a role in controlling pain of various etiologies in the ED with a potential to reduce the need for co-analgesics or rescue analgesic administration. There is a need for more robust, prospective, randomized trials that will further evaluate the analgesic efficacy and safety of this modality across a wide range of pain syndromes and different age groups in the ED.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "Ketamine, Analgesia, Emergency Department, Infusion"
        }
    ],
    "section": "Behavioral Health",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/78d9r96c",
    "frozenauthors": [
        {
            "first_name": "Sergey",
            "middle_name": "",
            "last_name": "Motov",
            "name_suffix": "",
            "institution": "Maimonides Medical Center, Department of Emergency Medicine, Brooklyn, New York",
            "department": "None"
        },
        {
            "first_name": "Jefferson",
            "middle_name": "",
            "last_name": "Drapkin",
            "name_suffix": "",
            "institution": "Maimonides Medical Center, Department of Emergency Medicine, Brooklyn, New York",
            "department": "None"
        },
        {
            "first_name": "Antonios",
            "middle_name": "",
            "last_name": "Likourezos",
            "name_suffix": "",
            "institution": "Maimonides Medical Center, Department of Emergency Medicine, Brooklyn, New York",
            "department": "None"
        },
        {
            "first_name": "Tyler",
            "middle_name": "",
            "last_name": "Beals",
            "name_suffix": "",
            "institution": "Maimonides Medical Center, Department of Emergency Medicine, Brooklyn, New York",
            "department": "None"
        },
        {
            "first_name": "Ralph",
            "middle_name": "",
            "last_name": "Monfort",
            "name_suffix": "",
            "institution": "Maimonides Medical Center, Department of Emergency Medicine, Brooklyn, New York",
            "department": "None"
        },
        {
            "first_name": "Christian",
            "middle_name": "",
            "last_name": "Fromm",
            "name_suffix": "",
            "institution": "Maimonides Medical Center, Department of Emergency Medicine, Brooklyn, New York",
            "department": "None"
        },
        {
            "first_name": "John",
            "middle_name": "",
            "last_name": "Marshall",
            "name_suffix": "",
            "institution": "Maimonides Medical Center, Department of Emergency Medicine, Brooklyn, New York",
            "department": "None"
        }
    ],
    "date_submitted": "2017-08-24T19:09:36Z",
    "date_accepted": "2017-08-24T19:09:36Z",
    "date_published": "2018-03-08T15:58:28Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/11249/galley/6102/download/"
        }
    ]
}