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{
    "pk": 1195,
    "title": "Legionnaires’ Disease Causing Severe Rhabdomyolysis and Acute Renal Failure: A Case Report",
    "subtitle": null,
    "abstract": "Introduction: \nLegionnaires’ disease is a multisystem disease involving respiratory, gastrointestinal, and neurologic systems. This is a case of a previously healthy 44-year-old man who was diagnosed with Legionella pneumonia causing acute kidney failure and rhabdomyolysis.\nCase Report:\n The patient presented with four days of chills, shortness of breath, chest discomfort, diarrhea, and myalgias. Laboratory testing revealed hyponatremia, leukocytosis, elevated inflammatory markers, renal failure, and rhabdomyolysis. He was admitted to the intensive care unit for acute hypoxemic respiratory failure, received a course of antibiotics, and more than two weeks of intermittent hemodialysis with full recovery of renal function. The pathophysiologic mechanisms by which Legionella causes rhabdomyolysis and acute kidney failure are not fully understood, although numerous mechanisms have been proposed including direct invasion of myocytes and renal tubular cells.\nConclusion: \nLegionnaires’ disease is one of several infections that can cause rhabdomyolysis and kidney failure. Although rarely described in the literature, it is important for emergency physicians to be aware of this clinical entity in order to implement early diagnostic testing and empiric treatment.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "Legionella"
        },
        {
            "word": "rhabdomyolysis"
        },
        {
            "word": "renal failure"
        },
        {
            "word": "emergency"
        },
        {
            "word": "case report"
        }
    ],
    "section": "Case Reports",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/2fz06709",
    "frozenauthors": [
        {
            "first_name": "Andrew",
            "middle_name": "",
            "last_name": "Branstetter",
            "name_suffix": "",
            "institution": "Mount Sinai Morningside-West, Department of Emergency Medicine, New York, New York",
            "department": "None"
        },
        {
            "first_name": "Benjamin",
            "middle_name": "",
            "last_name": "Wyler",
            "name_suffix": "",
            "institution": "Icahn School of Medicine at Mount Sinai, Department of Emergency Medicine, New York, New York",
            "department": "None"
        }
    ],
    "date_submitted": "2022-10-08T01:09:52+01:00",
    "date_accepted": "2022-10-08T01:09:52+01:00",
    "date_published": "2022-10-24T08:00:00+01:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uciem_cpcem/article/1195/galley/934/download/"
        }
    ]
}