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{
    "pk": 13268,
    "title": "Using Tenecteplase for Acute Ischemic Stroke:  What Is the Hold Up?",
    "subtitle": null,
    "abstract": "Alteplase is the only Food and Drug Administration-approved intravenous (IV) thrombolytic medication for acute ischemic stroke. However, multiple recent studies comparing tenecteplase and alteplase suggest that tenecteplase is at least as efficacious as alteplase with regards to neurologic improvement. When given at 0.25 milligrams per kilogram (mg/kg), tenecteplase may have less bleeding complications than alteplase as well. This narrative review evaluates the literature and addresses the practical issues with regards to the use of tenecteplase versus alteplase for acute ischemic stroke, and it recommends that physicians consider tenecteplase rather than alteplase for thrombolysis of acute ischemic stroke.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "thrombolytics, tenecteplase vs alteplase, tpa."
        }
    ],
    "section": "Commentary (Limit 2000 words)",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/4pz126bq",
    "frozenauthors": [
        {
            "first_name": "Tony",
            "middle_name": "",
            "last_name": "Zitek",
            "name_suffix": "",
            "institution": "Kendall Regional Medical Center, Department of Emergency Medicine, Miami, Florida\nNova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Department of Emergency Medicine, Fort Lauderdale, Florida",
            "department": "None"
        },
        {
            "first_name": "Ramsey",
            "middle_name": "",
            "last_name": "Ataya",
            "name_suffix": "",
            "institution": "Kendall Regional Medical Center, Department of Emergency Medicine, Miami, Florida",
            "department": "None"
        },
        {
            "first_name": "Isabel",
            "middle_name": "",
            "last_name": "Brea",
            "name_suffix": "",
            "institution": "Kendall Regional Medical Center, Department of Emergency Medicine, Miami, Florida\nNova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Department of Emergency Medicine, Fort Lauderdale, Florida",
            "department": "None"
        }
    ],
    "date_submitted": "2019-09-19T17:48:54Z",
    "date_accepted": "2019-09-19T17:48:54Z",
    "date_published": "2020-02-24T21:24:57Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/13268/galley/6987/download/"
        }
    ]
}