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{
    "pk": 14457,
    "title": "Utility Of An Emergency Department Clinical Protocol For Early Identification of Coronavirus Infection",
    "subtitle": null,
    "abstract": "Introduction:\n We assessed the utility of an emergency department (ED) protocol using clinical parameters to rapidly distinguish likelihood of novel coronavirus 2019 (COVID-19) infection; the applicability aimed to stratify infectious-risk pre-polymerase chain reaction (PCR) test results and accurately guide early patient cohorting decisions.\nMethods:\n We performed this prospective study over a two-month period during the initial surge of the 2020 COVID-19 pandemic in a busy urban ED of patients presenting with respiratory symptoms who were admitted for in-patient care. Per protocol, each patient received assessment consisting of five clinical parameters: presence of fever; hypoxia; cough; shortness of breath/dyspnea; and performance of a chest radiograph to assess for bilateral pulmonary infiltrates. All patients received nasopharyngeal COVID-19 PCR testing.\nResults: \nOf 283 patients studied, 221 (78%) were PCR+ and 62 (22%) PCR-. Chest radiograph revealed bilateral pulmonary infiltrates in 85%, which was significantly more common in PCR+ (94%) vs PCR- (52%) patients (P < 0.0001). The rate of manifesting all five positive clinical parameters was significantly greater in PCR+ (63%) vs PCR- (6.5%) patients (P < 0.0001). For PCR+ outcome, the presence of all five positive clinical parameters had a specificity of 94%, positive predictive value of 98%, and positive likelihood ratio of 10.\nConclusions:\n Using an ED protocol to rapidly assess five clinical parameters accurately distinguishes likelihood of COVID-19 infection prior to PCR test results, and can be used to augment early patient cohorting decisions.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "covid 19, emergency department, cohorting"
        }
    ],
    "section": "Endemic Infections",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/6s60f9nb",
    "frozenauthors": [
        {
            "first_name": "William",
            "middle_name": "",
            "last_name": "Bonadio",
            "name_suffix": "",
            "institution": "Mount Sinai Medical Center, Department of Emergency Medicine, New York City, New York",
            "department": "None"
        },
        {
            "first_name": "Kaedrea",
            "middle_name": "",
            "last_name": "Jackson",
            "name_suffix": "",
            "institution": "Mount Sinai Medical Center, Department of Emergency Medicine, New York City, New York",
            "department": "None"
        },
        {
            "first_name": "Lindsey",
            "middle_name": "",
            "last_name": "Gottlieb",
            "name_suffix": "",
            "institution": "Mount Sinai Medical Center, Department of Emergency Medicine, New York City, New York",
            "department": "None"
        },
        {
            "first_name": "Eric",
            "middle_name": "",
            "last_name": "Legome",
            "name_suffix": "",
            "institution": "Mount Sinai Medical Center, Department of Emergency Medicine, New York City, New York",
            "department": "None"
        }
    ],
    "date_submitted": "2020-08-09T12:43:34Z",
    "date_accepted": "2020-08-09T12:43:34Z",
    "date_published": "2021-04-05T18:54:40Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/14457/galley/7406/download/"
        }
    ]
}