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{
    "pk": 14604,
    "title": "Provider Antibody Serology Study of Virus in the Emergency Room (PASSOVER) Study: Special Population COVID-19 Seroprevalence",
    "subtitle": null,
    "abstract": "Introduction:\n Limited data on the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCW) are publicly available. In this study we sought to determine the seroprevalence of SARS-CoV-2 in a population of HCWs in a pediatric emergency department (ED).\nMethods: \nWe conducted this observational cohort study from April 14–May 13, 2020 in a pediatric ED in Orange County, CA. Asymptomatic HCW ≥18 years of age were included in the study. Blood samples were obtained by fingerstick at the start of each shift. The inter-sampling interval was ≤96 hours. The primary outcome was positive seroprevalence of SARS-CoV-2 as determined with an antibody fast detection kit (Colloidal Gold, Superbio, Timisoara, Romania) for the SARS-CoV-2 immunoglobulin M/immunoglobulin G (IgM/IgG) antibody.\nResults:\n A total of 143 HCWs participated in the study. Overall SARS-CoV-2 seroprevalence was 10.5% (n = 15). Positive seroprevalence was classified as IgG only (4.9%), IgM+IgG (3.5%), or IgM only (2.1%). SARS-CoV-2 was detected by reverse transcription polymerase chain reaction RT-PCR in 0.7% of the overall study population (n = 1). Samples obtained on Day 1 indicated seropositivity in 4.2% of the study population (n = 6). Subsequent seroconversion occurred in 6.3% of participants (n = 9). The rate of seroconversion was linear with a rate of approximately one new case every two days, starting at Day 9 of the study.\nConclusion:\n We observed a linear rate of seroconversion to SARS-CoV-2–positive status among asymptomatic HCWs who underwent daily symptom surveys and temperature screens in an environment with universal source control. Rapid antibody testing may be useful for screening for SARS-CoV-2 seropositivity in high-risk populations, such as HCWs in the ED.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "COVID-19, seroprevalence, emergency medicine"
        }
    ],
    "section": "Endemic Infections",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/4rv6721f",
    "frozenauthors": [
        {
            "first_name": "Theodore",
            "middle_name": "W.",
            "last_name": "Heyming",
            "name_suffix": "",
            "institution": "Children’s Hospital of Orange County, Department of Emergency Medicine, Orange, California\nUniversity of California, Irvine, Department of Emergency Medicine, Irvine, California",
            "department": "None"
        },
        {
            "first_name": "Terence",
            "middle_name": "",
            "last_name": "Sanger",
            "name_suffix": "",
            "institution": "University of California, Irvine, Department of Electrical Engineering and Computer Science, Irvine, California\nChildren’s Hospital of Orange County, Research Institute, Orange, California",
            "department": "None"
        },
        {
            "first_name": "Aprille",
            "middle_name": "",
            "last_name": "Tongol",
            "name_suffix": "",
            "institution": "Children’s Hospital of Orange County, Research Institute, Orange, California",
            "department": "None"
        },
        {
            "first_name": "John",
            "middle_name": "",
            "last_name": "Schomberg",
            "name_suffix": "",
            "institution": "Children’s Hospital of Orange County, Department of Nursing, Orange, California",
            "department": "None"
        },
        {
            "first_name": "Kellie",
            "middle_name": "",
            "last_name": "Bacon",
            "name_suffix": "",
            "institution": "Children’s Hospital of Orange County, Research Institute, Orange, California",
            "department": "None"
        },
        {
            "first_name": "Bryan",
            "middle_name": "",
            "last_name": "Lara",
            "name_suffix": "",
            "institution": "Children’s Hospital of Orange County, Research Institute, Orange, California",
            "department": "None"
        }
    ],
    "date_submitted": "2020-09-28T19:13:49+02:00",
    "date_accepted": "2020-09-28T19:13:49+02:00",
    "date_published": "2021-04-10T01:58:41+02:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/14604/galley/7453/download/"
        }
    ]
}