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{
    "pk": 1573,
    "title": "A Case Report: Lurasidone-Induced Type 2 Brugada Pattern in a Pediatric Patient",
    "subtitle": null,
    "abstract": "<p><strong>Introduction</strong>: Brugada syndrome, a cardiac channelopathy, manifests with ventricular arrhythmia. Diagnosis relies on a type 1 Brugada electrocardiogram (ECG) pattern, while type 2 and type 3 patterns may necessitate electrophysiologic testing to uncover an underlying type 1 Brugada pattern. Differentiation between these patterns is important, as type 1 patterns pose a significantly greater risk of arrhythmia relative to types 2 and 3 counterparts.</p>\n<p><strong>Case Report</strong>: A 14-year-old male with autism presented after a syncopal episode following a lurasidone dosage increase. His ECG revealed a type 2 Brugada pattern. He was monitored<br>overnight in the pediatric intensive care unit, where he remained asymptomatic. After being discharged with a Holter monitor, a quaternary hospital’s procainamide challenge test weeks later contradicted an official diagnosis of Brugada syndrome, as dictated by elucidation of a type 1 Brugada pattern. After reverting to the initial lurasidone dose, a follow-up ECG after two months showed no Brugada pattern.</p>\n<p><strong>Conclusion</strong>: In syncope cases, an ECG is crucial for identifying arrhythmogenic causes, including Brugada syndrome. This case highlights an ECG suggestive of Brugada syndrome with negative pharmacological tests and resolution post-discontinuation of the offending agent. Emergency physicians should be vigilant for Brugada and long QT syndromes in patients on antipsychotic medications.</p>",
    "language": "eng",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "Brugada"
        },
        {
            "word": "pediatric"
        },
        {
            "word": "case report"
        },
        {
            "word": "lurasidone"
        },
        {
            "word": "anti-psychotic"
        }
    ],
    "section": "Case Reports",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/1mz6g9hb",
    "frozenauthors": [
        {
            "first_name": "Ethan",
            "middle_name": "",
            "last_name": "Start",
            "name_suffix": "",
            "institution": "University of Florida – Jacksonville, Department of Emergency Medicine, Jacksonville, Florida",
            "department": ""
        },
        {
            "first_name": "Jan Aldrin",
            "middle_name": "Guevarra",
            "last_name": "Enabore",
            "name_suffix": "",
            "institution": "Prisma Health - Upstate, Department of Emergency Medicine, Greenville, South Carolina",
            "department": ""
        }
    ],
    "date_submitted": "2023-11-28T19:48:48.165000Z",
    "date_accepted": "2024-06-20T19:02:03.731000Z",
    "date_published": "2025-05-28T18:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "PDF",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/uciem_cpcem/article/1573/galley/38475/download/"
        }
    ]
}