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{
    "pk": 15996,
    "title": "Clue Cells on Vaginal Wet Preparation Are Not Associated with Urinary Tract Infections or Positive Urine Cultures",
    "subtitle": null,
    "abstract": "Introduction: Clue cells result from aberrant vaginal microflora and are associated with an increased vaginal pH, which can allow colonization of uropathogens in the vaginal introitus, increasing the risk for urinary tract infections (UTI). We sought to determine whether clue cells on vaginal wet preparation in the emergency department (ED) are associated with emergency physician diagnoses of UTIs and positive urine cultures.\nMethods: We conducted a retrospective analysis examining a dataset of women (≥18 years of age) who received both a genital wet preparation and urine testing in the ED. Both chi-square and multivariable regression analysis were performed.\nResults: We analyzed 14,952 encounters. On both univariable and multivariable analyses, emergency physicians diagnosed significantly fewer clue cell-positive women with a UTI (10.9% diagnosed with UTI vs 13.1% without UTI) (P <.001). Women with clue cells on vaginal wet preparation were not more likely to have a positive urine culture or have a urine culture growing Escherichia coli. Pregnant women with clue cells on vaginal wet preparation were not more likely to have a UTI or have a positive urine culture.\nConclusion: Emergency physicians diagnosed significantly fewer women with UTIs when they found clue cells on vaginal wet preparation. Clue cells on vaginal wet preparation were not associated with an increased likelihood of a positive urine culture or having E. coli growing in the urine.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "clue cells, bacterial vaginosis, urinary tract infection, cystitis, urine culture, bacteriuria, Escherichia coli"
        }
    ],
    "section": "Clinical Practice",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/27j5g82k",
    "frozenauthors": [
        {
            "first_name": "Johnathan",
            "middle_name": "Michael",
            "last_name": "Sheele",
            "name_suffix": "",
            "institution": "Mayo Clinic, Department of Emergency Medicine, Jacksonville, Florida",
            "department": "None"
        },
        {
            "first_name": "Carolyn",
            "middle_name": "",
            "last_name": "Mead-Harvey",
            "name_suffix": "",
            "institution": "Mayo Clinic, Division of Clinical Trials and Biostatistics, Phoenix, Arizona",
            "department": "None"
        },
        {
            "first_name": "Nicole",
            "middle_name": "",
            "last_name": "Hodgson",
            "name_suffix": "",
            "institution": "Mayo Clinic, Department of Emergency Medicine, Phoenix, Arizona",
            "department": "None"
        }
    ],
    "date_submitted": "2021-10-06T18:00:43Z",
    "date_accepted": "2021-10-06T18:00:43Z",
    "date_published": "2022-06-19T00:06:12Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/15996/galley/8018/download/"
        }
    ]
}