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{
    "pk": 16745,
    "title": "Management and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study",
    "subtitle": null,
    "abstract": "Introduction: \nFew studies have investigated the management of COVID-19 cases from the operational perspective of the emergency department (ED), We sought to compare the management and outcome of COVID-19 positive and negative patients who presented to French EDs.\nMethods: \nWe conducted a prospective, multicenter, observational study in four EDs. Included in the study were adult patients (≥18 years) between March 6–May 10, 2020, were hospitalized, and whose presenting symptoms were evocative of COVID-19. We compared the clinical features, management, and prognosis of patients according to their confirmed COVID-19 status.\nResults:\n Of the 2,686 patients included in this study, 760 (28.3%) were COVID-19 positive. Among them, 364 (48.0%) had hypertension, 228 (30.0%) had chronic cardiac disease, 186 (24.5%) had diabetes, 126 (16.6%) were obese, and 114 (15.0%) had chronic respiratory disease. The proportion of patients admitted to intensive care units (ICU) was higher among COVID-19 positive patients (185/760, 24.3%) compared to COVID-19 negative patients (206/1,926, 10.7%; P <0.001), and they required mechanical ventilation (89, 11.9% vs 37, 1.9%; P <0.001) and high-flow nasal cannula oxygen therapy (135, 18.1% vs 41, 2.2%; P < 0.001) more frequently. The in-hospital mortality was significantly higher among COVID-19 positive patients (139, 18.3% vs 149, 7.7%; P <0.001).\nConclusion:\n Emergency departments were on the frontline during the COVID-19 pandemic and had to manage potential COVID-19 patients. Understanding what happened in the ED during this first outbreak is crucial to underline the importance of flexible organizations that can quickly adapt the bed capacities to the incoming flow of COVID-19 positive patients.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "COVID-19"
        },
        {
            "word": "Mortality"
        },
        {
            "word": "Hospitalization"
        },
        {
            "word": "emergency department."
        }
    ],
    "section": "Endemic Infections",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/6sp546qh",
    "frozenauthors": [
        {
            "first_name": "Marion",
            "middle_name": "",
            "last_name": "Douplat",
            "name_suffix": "",
            "institution": "Hospices Civils of Lyon, \n\tLyon Sud Hospital,\nEmergency department \n\tPierre Bénite F-69495\n\t\nUniversité Claude Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), INSERM U1290, Lyon, France \n\nUMR ADéS 7268  \nAix-Marseille University/ EFS / CNRS\nEspace éthique méditerranéen\nMarseille,France",
            "department": "None"
        },
        {
            "first_name": "Antoine",
            "middle_name": "",
            "last_name": "Gavoille",
            "name_suffix": "",
            "institution": "Université de Lyon Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Évolutive UMR 5558, Villeurbanne, France; Service de Biostatistique, Hospices Civils de Lyon, Lyon France",
            "department": "None"
        },
        {
            "first_name": "Fabien",
            "middle_name": "",
            "last_name": "Subtil",
            "name_suffix": "",
            "institution": "Université de Lyon Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Évolutive UMR 5558, Villeurbanne, France; Service de Biostatistique, Hospices Civils de Lyon, Lyon France",
            "department": "None"
        },
        {
            "first_name": "Julie",
            "middle_name": "",
            "last_name": "Haesebaert",
            "name_suffix": "",
            "institution": "Université Claude Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), INSERM U1290, Lyon, France; Pôle de Santé Publique, Service de Recherche et d’Epidémiologie Cliniques, Hospices Civils de Lyon, France",
            "department": "None"
        },
        {
            "first_name": "Laurent",
            "middle_name": "",
            "last_name": "Jacquin",
            "name_suffix": "",
            "institution": "Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Emergency Medicine, Lyon, France",
            "department": "None"
        },
        {
            "first_name": "Guillaume",
            "middle_name": "",
            "last_name": "Durand",
            "name_suffix": "",
            "institution": "Villefranche Hospital, Department of Emergency Medicine, Gleize, France",
            "department": "None"
        },
        {
            "first_name": "Jean-Christophe",
            "middle_name": "",
            "last_name": "Lega",
            "name_suffix": "",
            "institution": "Hospices Civils de Lyon, Lyon Sud Hospital, Department of Internal and Vascular \nMedicine, Pierre Bénite, France",
            "department": "None"
        },
        {
            "first_name": "Thomas",
            "middle_name": "",
            "last_name": "Perpoint",
            "name_suffix": "",
            "institution": "Service de Maladies Infectieuses et Tropicales, Hôpital Croix-Rousse Hospices Civils de Lyon, Lyon, France",
            "department": "None"
        },
        {
            "first_name": "Veronique",
            "middle_name": "",
            "last_name": "Potinet",
            "name_suffix": "",
            "institution": "Hospices Civils de Lyon, Lyon Sud Hospital, Department of Emergency Medicine, Pierre Bénite, France",
            "department": "None"
        },
        {
            "first_name": "Julien",
            "middle_name": "",
            "last_name": "Berthiller",
            "name_suffix": "",
            "institution": "Pôle de Santé Publique, Service de Recherche et d’Epidémiologie Cliniques, Hospices Civils de Lyon, France",
            "department": "None"
        },
        {
            "first_name": "Nathalie",
            "middle_name": "",
            "last_name": "Perreton",
            "name_suffix": "",
            "institution": "Pôle de Santé Publique, Service de Recherche et d’Epidémiologie Cliniques, Hospices Civils de Lyon, France",
            "department": "None"
        },
        {
            "first_name": "Karim",
            "middle_name": "",
            "last_name": "Tazarourte",
            "name_suffix": "",
            "institution": "Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Emergency Medicine, Lyon, France",
            "department": "None"
        }
    ],
    "date_submitted": "2022-04-14T16:26:46-04:00",
    "date_accepted": "2022-04-14T16:26:46-04:00",
    "date_published": "2022-10-24T18:33:20-04:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/16745/galley/8479/download/"
        }
    ]
}