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{
    "pk": 17185,
    "title": "Comparability of Results Between a Point-of-Care and an Automated Instrument for Measurement of B-Type Natriuretic Peptide",
    "subtitle": null,
    "abstract": "Objectives: Heart failure is one of the leading causes of death in the U.S. The incorporation of B-type natriuretic peptide (BNP) measurements when triaging patients presenting with shortness of breath has improved the diagnostic and prognostic ability of physicians. Currently, there are no point-of-care systems for quantifying BNP that can be used without sacrificing accuracy. We compared the analytical performance of the Abbott i-STAT analyzer, a handheld point-of-care system for measuring BNP, with the lab-based system, the Abbott ARCHITECT.\n\n\nMethods: One-hundred fifty samples were collected from three clinical settings: 41 from the Emergency Department, 58 from the inpatient wards, and 51 from heart failure outpatient clinics. Linear regression and bias difference analyses were run to evaluate the accuracy of the i-STAT. Correlation between the i-STAT and Architect BNP values were made with values of BNP.\n\n\nResults: The correlation coefficient was r=0.977 (N=150, p<.0001). The average bias was significant (-36) and there were concentration-dependent differences at higher BNP values. Precision of the i-STAT was poor compared to the lab-based platform.\n\n\nConclusion: Although the precision of the i-STAT was poor, there was good clinical agreement between the i-STAT and the lab-based platform. [West J Emerg Med. 2010; 11(1):44-48].",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution-NonCommercial  4.0",
        "short_name": "CC BY-NC 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNonCommercial — You may not use the material for commercial purposes.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by-nc/4.0"
    },
    "keywords": [
        {
            "word": "i-STAT"
        },
        {
            "word": "Architect"
        },
        {
            "word": "Heart Failure"
        },
        {
            "word": "Natriuretic Peptide"
        },
        {
            "word": "BNP"
        },
        {
            "word": "Emergency Medicine"
        }
    ],
    "section": "Article",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/4qj8k661",
    "frozenauthors": [
        {
            "first_name": "Kevin",
            "middle_name": "",
            "last_name": "Shah",
            "name_suffix": "",
            "institution": "Veterans Administration San Diego Healthcare System, Cardiology, La Jolla, CA",
            "department": "None"
        },
        {
            "first_name": "Garrett",
            "middle_name": "J",
            "last_name": "Terracciano",
            "name_suffix": "",
            "institution": "University of California, San Diego School of Medicine, La Jolla, CA",
            "department": "None"
        },
        {
            "first_name": "Kevin",
            "middle_name": "",
            "last_name": "Jiang",
            "name_suffix": "",
            "institution": "Veterans Administration San Diego Healthcare System, Cardiology, La Jolla, CA",
            "department": "None"
        },
        {
            "first_name": "Alan",
            "middle_name": "S",
            "last_name": "Maisel",
            "name_suffix": "",
            "institution": "Veterans Administration San Diego Healthcare System, Cardiology, La Jolla, CA; University of California, San Diego, Medicine",
            "department": "None"
        },
        {
            "first_name": "Robert",
            "middle_name": "L",
            "last_name": "Fitzgerald",
            "name_suffix": "",
            "institution": "Veterans Administration San Diego Healthcare System, Pathology. University of California, San Diego, Pathology",
            "department": "None"
        }
    ],
    "date_submitted": "2009-04-06T07:00:00Z",
    "date_accepted": "2009-04-06T07:00:00Z",
    "date_published": "2010-04-02T07:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/17185/galley/8685/download/"
        }
    ]
}