Article Instance

HTTP 200 OK
Allow: GET
Content-Type: application/json
Vary: Accept

{
    "pk": 17654,
    "title": "Prognostic Accuracy of SpO2-based Respiratory Sequential Organ Failure Assessment for Predicting In-hospital Mortality",
    "subtitle": null,
    "abstract": "Introduction: \nIn this study we aimed to investigate the prognostic accuracy for predicting in-hospital mortality using respiratory Sequential Organ Failure Assessment (SOFA) scores by the conventional method of missing-value imputation with normal partial pressure of oxygen (PaO2)- and oxygen saturation (SpO2)-based estimation methods.\nMethods:\n This was a single-center, retrospective cohort study of patients with suspected infection in the emergency department. The primary outcome was in-hospital mortality. We compared the area under the receiver operating characteristics curve (AUROC) and calibration results of the conventional method (normal value imputation for missing PaO2) and six SpO2-based methods: using methods A, B, PaO2 is estimated by dividing SpO2 by a scale; with methods C and D, PaO2 was estimated by a mathematical model from a previous study; with methods E, F, respiratory SOFA scores was estimated by SpO2 thresholds and respiratory support use; with methods A, C, E are SpO2-based estimation for all PaO2 values, while methods B, D, F use such estimation only for missing PaO2 values.\nResults:\n Among the 15,119 patients included in the study, the in-hospital mortality rate was 4.9%. The missing PaO2was 56.0%. The calibration plots were similar among all methods. Each method yielded AUROCs that ranged from 0.735–0.772. The AUROC for the conventional method was 0.755 (95%confidence interval [CI] 0.736–0.773). The AUROC for method C (0.772; 95% CI 0.754–0.790) was higher than that of the conventional method, which was an SpO2-based estimation for all PaO2 values. The AUROC for total SOFA score from method E (0.815; 95% CI 0.800–0.831) was higher than that from the conventional method (0.806; 95% CI 0.790–0.822), in which respiratory SOFA was calculated by the predefined SpO2 cut-offs and oxygen support.\nConclusion: \nIn non-ICU settings, respiratory SOFA scores estimated by SpO2 might have acceptable prognostic accuracy for predicting in-hospital mortality. Our results suggest that SpO2-based respiratory SOFA score calculation might be an alternative for evaluating respiratory organ failure in the ED and clinical research settings.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "Sequential Organ Failure Assessment scores"
        },
        {
            "word": "Pulse oximetry"
        },
        {
            "word": "sepsis"
        },
        {
            "word": "respiratory failure"
        }
    ],
    "section": "Critical Care",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/1jb997v3",
    "frozenauthors": [
        {
            "first_name": "Daun",
            "middle_name": "",
            "last_name": "Jeong",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Gun Tak",
            "middle_name": "",
            "last_name": "Lee",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Jong Eun",
            "middle_name": "",
            "last_name": "Park",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Sung Yeon",
            "middle_name": "",
            "last_name": "Hwang",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Taerim",
            "middle_name": "",
            "last_name": "Kim",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Se Uk",
            "middle_name": "",
            "last_name": "Lee",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Hee",
            "middle_name": "",
            "last_name": "Yoon",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Won Chul",
            "middle_name": "",
            "last_name": "Cha",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Min Seob",
            "middle_name": "",
            "last_name": "Sim",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Ik Joon",
            "middle_name": "",
            "last_name": "Jo",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        },
        {
            "first_name": "Tae Gun",
            "middle_name": "",
            "last_name": "Shin",
            "name_suffix": "",
            "institution": "Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Emergency Medicine, Seoul, Korea",
            "department": "None"
        }
    ],
    "date_submitted": "2022-11-15T00:17:16-08:00",
    "date_accepted": "2022-11-15T00:17:16-08:00",
    "date_published": "2023-09-25T12:37:05-07:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/17654/galley/9012/download/"
        }
    ]
}