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{
    "pk": 17740,
    "title": "Improving Diagnostic Accuracy of Anaphylaxis in the Acute Care Setting",
    "subtitle": null,
    "abstract": "The identification and appropriate management of those at highest risk for life-threatening anaphylaxis remains a clinical enigma. The most widely used criteria for such patients were developed in a symposium convened by National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network. In this paper we review the current literature on the diagnosis of acute allergic reactions as well as atypical presentations that clinicians should recognize. Review of case series reveals significant variability in definition and approach to this common and potentially life-threatening condition. Series on fatal cases of anaphylaxis indicate that mucocutaneous signs and symptoms occur less frequently than in milder cases. Of biomarkers studied to aid in the work-up of possible anaphylaxis, drawing blood during the initial six hours of an acute reaction for analysis of serum tryptase has been recommended in atypical cases. This can provide valuable information when a definitive diagnosis cannot be made by history and physical exam. [West J Emerg Med. 2010; 11(5); 456-461.]",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution-NonCommercial  4.0",
        "short_name": "CC BY-NC 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNonCommercial — You may not use the material for commercial purposes.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by-nc/4.0"
    },
    "keywords": [
        {
            "word": "anaphylaxis"
        },
        {
            "word": "Tryptase"
        },
        {
            "word": "Emergency Medicine"
        },
        {
            "word": "Allergy and Immunology"
        }
    ],
    "section": "Article",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/0rt1s57j",
    "frozenauthors": [
        {
            "first_name": "Hjalti",
            "middle_name": "M",
            "last_name": "Bjornsson",
            "name_suffix": "",
            "institution": "Eastern Virginia Medical School, Department of Emergency Medicine, Norfolk, VA",
            "department": "None"
        },
        {
            "first_name": "Charles",
            "middle_name": "S",
            "last_name": "Graffeo",
            "name_suffix": "",
            "institution": "Eastern Virginia Medical School, Department of Emergency Medicine, Norfolk, VA",
            "department": "None"
        }
    ],
    "date_submitted": "2009-07-29T07:00:00Z",
    "date_accepted": "2009-07-29T07:00:00Z",
    "date_published": "2010-11-10T08:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/17740/galley/9059/download/"
        }
    ]
}