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{
    "pk": 18367,
    "title": "Association Between Platelet-to-Lymphocyte Ratio and In-hospital Mortality in Elderly Patients with Severe Trauma",
    "subtitle": null,
    "abstract": "Introduction:\n The platelet-to-lymphocyte ratio (PLR) is associated with the inflammatory response in various diseases. However, studies on the use of the PLR for the prognosis of elderly patients with severe trauma are lacking. In this study, we examined the relationship between the PLR and in-hospital mortality in elderly patients with severe trauma.\nMethods:\n This retrospective observational study included elderly (≥65 years) patients who were admitted for severe trauma (as defined by an Injury Severity Score [ISS] ≥ 16) between January–December 2022. We conducted multivariate analysis to assess the association between the PLR and in-hospital mortality using logistic regression of relevant covariates. We also performed receiver operating characteristic curve analysis to examine the prognostic performance of the PLR forin-hospital mortality.\nResults:\n Among the 222 patients included in the study, the in-hospital mortality rate was 19.4% (43). The PLR of non-survivors was lower than that of survivors (62.1 vs 124.5). The areas under the curve (AUC) of the Glasgow Coma Scale (GCS) score ≤12, ISS, hemoglobin level, and PLR for predicting in-hospital mortality were 0.730 (95% confidence interval [CI] 0.667–0.787), 0.771 (95% CI 0.710–0.824), 0.657 (95% CI 0.591–0.719), and 0.730 (95% CI 0.667–0.788), respectively. The AUC of the PLR was not significantly different from that of GCS score ≤12 and ISS for predicting in-hospital mortality. Multivariate analysis showed that the PLR was independently associated with in-hospital mortality (odds ratio: 0.993; 95% CI 0.987–0.999).\nConclusion: \nLow platelet-to-lymphocyte ratio is independently associated with in-hospital mortality in elderly patients with severe trauma.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "Age, trauma, platelet, lymphocyte, prognosis"
        }
    ],
    "section": "Trauma",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/6ht1w2zh",
    "frozenauthors": [
        {
            "first_name": "Jiho",
            "middle_name": "",
            "last_name": "Lee",
            "name_suffix": "",
            "institution": "Chonnam National University Hospital, Department of Emergency Medicine, Gwangju, Republic of Korea",
            "department": "None"
        },
        {
            "first_name": "Dong Hun",
            "middle_name": "",
            "last_name": "Lee",
            "name_suffix": "",
            "institution": "Chonnam National University Hospital, Department of Emergency Medicine, Gwangju, Republic of Korea; Chonnam National University Medical School, Department of Emergency Medicine, Gwangju, Republic of Korea",
            "department": "None"
        },
        {
            "first_name": "Byung Kook",
            "middle_name": "",
            "last_name": "Lee",
            "name_suffix": "",
            "institution": "Chonnam National University Hospital, Department of Emergency Medicine, Gwangju, Republic of Korea; Chonnam National University Medical School, Department of Emergency Medicine, Gwangju, Republic of Korea",
            "department": "None"
        }
    ],
    "date_submitted": "2023-06-12T01:50:50+01:00",
    "date_accepted": "2023-06-12T01:50:50+01:00",
    "date_published": "2024-01-04T19:02:21Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/18367/galley/9431/download/"
        }
    ]
}