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{
    "pk": 18589,
    "title": "The Nonlinear Relationship Between Temperature and Prognosis in Sepsis-induced Coagulopathy Patients: A Retrospective Cohort Study from MIMIC-IV Database",
    "subtitle": null,
    "abstract": "<p><strong>Background: </strong>The prognostic value of body temperature in sepsis-induced coagulopathy (SIC) remains unclear. In this study we aimed to investigate the association between temperature and mortality among SIC patients.</p>\n<p><strong>Methods: </strong>We analyzed data for 9,860 SIC patients from an intensive care database. Patients were categorized by maximum temperature in the first 24 hours into the following: ≤36.0°C; 36.0–37.0°C; 37.0–38.0°C; 38.0–39.0°C; and ≥39.0°C. The primary outcome was 28-day mortality. We used multivariate regression to analyze the temperature-mortality association.</p>\n<p><strong>Results: </strong>The 37.0–38.0°C, 38.0–39.0°C and ≥39.0°C groups correlated with lower 28-day mortality (adjusted HR 0.70, 0.76 and 0.72, respectively), while the &lt;36.0°C group correlated with higher mortality compared to the 36.0–37.0°C group (adjusted HR 2.60). A nonlinear relationship was observed between temperature and mortality. Subgroup analysis found no effect modification except in cerebrovascular disease.</p>\n<p><strong>Conclusion: </strong>A body temperature in the range of 37.0–38.0°C was associated with a significantly lower mortality compared to the normal temperature (36.0–37.0°C) group. Additionally, a gradual but statistically insignificant increase in mortality risk was observed when body temperature exceeded 38.0°C. Further research should validate these findings and elucidate involved mechanisms, especially in cerebrovascular disease subgroups.</p>",
    "language": null,
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "Sepsis-induced coagulopathy"
        },
        {
            "word": "temperature"
        },
        {
            "word": "Hypothermia"
        },
        {
            "word": "fever"
        },
        {
            "word": "Mortality"
        },
        {
            "word": "Prognosis"
        }
    ],
    "section": "Critical Care",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/2pd307kp",
    "frozenauthors": [
        {
            "first_name": "Guojun",
            "middle_name": "",
            "last_name": "Chen",
            "name_suffix": "",
            "institution": "First People’s Hospital of Foshan, Department of Emergency, Foshan, Guangdong, China; First People’s Hospital of Foshan, The Poison Treatment Centre of Foshan, Foshan, Guangdong, China",
            "department": ""
        },
        {
            "first_name": "Tianen",
            "middle_name": "",
            "last_name": "Zhou",
            "name_suffix": "",
            "institution": "First People’s Hospital of Foshan, Department of Emergency, Foshan, Guangdong, China; First People’s Hospital of Foshan, The Poison Treatment Centre of Foshan, Foshan, Guangdong, China",
            "department": "None"
        },
        {
            "first_name": "Jingtao",
            "middle_name": "",
            "last_name": "Xu",
            "name_suffix": "",
            "institution": "First People’s Hospital of Foshan, Department of Emergency, Foshan, Guangdong, China; First People’s Hospital of Foshan, The Poison Treatment Centre of Foshan, Foshan, Guangdong, China",
            "department": "None"
        },
        {
            "first_name": "Qiaohua",
            "middle_name": "",
            "last_name": "Hu",
            "name_suffix": "",
            "institution": "First People’s Hospital of Foshan, Department of Emergency, Foshan, Guangdong, China; First People’s Hospital of Foshan, The Poison Treatment Centre of Foshan, Foshan, Guangdong, China",
            "department": "None"
        },
        {
            "first_name": "Jun",
            "middle_name": "",
            "last_name": "Jiang",
            "name_suffix": "",
            "institution": "First People’s Hospital of Foshan, Department of Emergency, Foshan, Guangdong, China; First People’s Hospital of Foshan, The Poison Treatment Centre of Foshan, Foshan, Guangdong, China",
            "department": "None"
        },
        {
            "first_name": "Weigan",
            "middle_name": "",
            "last_name": "Xu",
            "name_suffix": "",
            "institution": "First People’s Hospital of Foshan, Department of Emergency, Foshan, Guangdong, China; First People’s Hospital of Foshan, The Poison Treatment Centre of Foshan, Foshan, Guangdong, China",
            "department": "None"
        }
    ],
    "date_submitted": "2023-11-19T21:23:50+05:30",
    "date_accepted": "2024-04-19T04:50:29.379000+05:30",
    "date_published": "2024-08-16T18:30:00+05:30",
    "render_galley": {
        "label": "Final Article",
        "type": "pdf",
        "path": "https://journalpub.escholarship.org/westjem/article/18589/galley/25959/download/"
    },
    "galleys": [
        {
            "label": "Layout",
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            "path": "https://journalpub.escholarship.org/westjem/article/18589/galley/14648/download/"
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        {
            "label": "Final Article",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/18589/galley/25959/download/"
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}