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{
    "pk": 20448,
    "title": "Immune Checkpoint Inhibitor-Induced Primary Adrenal Insufficiency: A Case Report",
    "subtitle": null,
    "abstract": "<p><strong>Introduction:</strong> One of the less common and more life-threatening etiologies of adrenal insufficiency is immune checkpoint inhibitor (ICI)-induced primary adrenal insufficiency (PAI). Patients typically present with fatigue, malaise, and nausea and are treated empirically with hydrocortisone.  </p>\n<p><strong>Case Report:</strong> We present the case of a 59-year-old female who presented with hypotension, which initially was thought to be due to hypovolemia or medication-related, but was ultimately found to have PAI. </p>\n<p><strong>Conclusion:</strong> This case highlights the importance of early detection of ICI-induced primary adrenal insufficiency, given its associated morbidity and mortality and its incidence in patients with a history of immunotherapy.</p>",
    "language": "eng",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "Immunotherapy"
        },
        {
            "word": "shock"
        },
        {
            "word": "adrenal insufficiency"
        },
        {
            "word": "immune checkpoint inhibitor"
        },
        {
            "word": "case report"
        }
    ],
    "section": "Case Reports",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/8nx589cr",
    "frozenauthors": [
        {
            "first_name": "Rahul",
            "middle_name": "",
            "last_name": "Gupta",
            "name_suffix": "",
            "institution": "Cooper University Hospital, Department of Emergency Medicine, Camden, New Jersey",
            "department": ""
        },
        {
            "first_name": "Cary",
            "middle_name": "",
            "last_name": "Lubkin",
            "name_suffix": "",
            "institution": "Cooper University Hospital, Department of Emergency Medicine, Camden, New Jersey",
            "department": ""
        }
    ],
    "date_submitted": "2024-03-25T03:29:06.456000Z",
    "date_accepted": "2024-06-29T09:09:58.386000Z",
    "date_published": "2024-08-26T16:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "PDF",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/uciem_cpcem/article/20448/galley/30155/download/"
        }
    ]
}