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{
    "pk": 20771,
    "title": " A computational model for individual epithelial cells captures how shape dynamics depend on cell size   ",
    "subtitle": null,
    "abstract": "<p>&nbsp;The dynamics of epithelial cells during wound healing exhibit significant complexity, notably in their size-dependent behavior. This work aims to depict a fundamental mechanism underlying this size dependence in cellular dynamics by developing a computational model. Our research question investigates how the physical size of epithelial cells influences their motility and behavior patterns, specifically during the epithelial-to-mesenchymal transition critical for wound healing. Thus, we propose a model where the key mechanism involves a field of spatially coupled forces acting on the cell membrane, driven by the dynamics of actin monomers. These monomers, randomly distributed within the cell, become focal points for membrane protrusions, thus influencing cell behavior. Our model succinctly captures the essence of size-dependent cellular dynamics without resorting to changes in gene expression patterns, offering new insights into the variations in cell behavior. Through this computational framework, we demonstrate that the diversity in cellular responses during wound healing can be fundamentally attributed to differences in cell size. This insight contributes to a deeper understanding of the behavioral plasticity of epithelial cells in critical physiological processes like wound closure.&nbsp;</p>",
    "language": "eng",
    "license": {
        "name": "Creative Commons Attribution-NonCommercial  4.0",
        "short_name": "CC BY-NC 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNonCommercial — You may not use the material for commercial purposes.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by-nc/4.0"
    },
    "keywords": [
        {
            "word": "Epithelial-to-Mesenchymal Transition"
        },
        {
            "word": "Size-Dependent Dynamics"
        },
        {
            "word": "Computational Model"
        },
        {
            "word": "Protrusions"
        },
        {
            "word": "Computational Software"
        },
        {
            "word": "Wound-closure"
        }
    ],
    "section": "Articles",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/7gf8s5m6",
    "frozenauthors": [
        {
            "first_name": "Rayan",
            "middle_name": "",
            "last_name": "Awais",
            "name_suffix": "",
            "institution": "",
            "department": ""
        }
    ],
    "date_submitted": "2024-04-05T21:24:59.394000Z",
    "date_accepted": "2024-04-30T19:52:00.480000Z",
    "date_published": "2024-06-07T07:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "Rayan Awais",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/ucr_undergrad_research_j/article/20771/galley/28632/download/"
        },
        {
            "label": "Rayan Awais",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/ucr_undergrad_research_j/article/20771/galley/28633/download/"
        }
    ]
}