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{
    "pk": 28419,
    "title": "Genetics and Experience Modulate Individual Differences in Navigation",
    "subtitle": null,
    "abstract": "Different memory systems, dependent on separate parts of the brain, can sustain successful\nnavigation. The hippocampus is implicated in spatial memory strategies used when finding one’s\nway in the environment, i.e. it is allocentric and involves remembering the relationship between\nlandmarks. On the other hand, another strategy dependent on the caudate nucleus can also be\nused, i.e. the response strategy, which relies on making a series of stimulus-response associations\n(e.g. right and left turns from given positions). Participants who use the response strategy are\nfaster at learning navigation tasks lending themselves to using a single specified route. Young\nadult response learners have increased fMRI activity and grey matter in the caudate nucleus, but\ndecreased fMRI activity and grey matter in the hippocampus. Research in my laboratory has\nshown that specific navigation strategies are associated with several genes, such as BDNF and\nApoE, as well as hormones, such as cortisol and progesterone, but not estrogen and progesterone.\nExperiences dependent modulators such as age, habit, stress and rewards also modulate strategies\ndependent on the hippocampus and caudate nucleus. These results have important translational\nimplications because a larger hippocampus has been associated with healthy cognition in normal\naging and with a reduced risk of numerous neurological and psychiatric disorders such as\nAlzheimer’s disease, Schizophrenia, Post-Traumatic Stress disorder and Depression.",
    "language": "eng",
    "license": {
        "name": "",
        "short_name": "",
        "text": null,
        "url": ""
    },
    "keywords": [],
    "section": "Symposia",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/7dk1h1rw",
    "frozenauthors": [
        {
            "first_name": "Veronique",
            "middle_name": "",
            "last_name": "Bohbot",
            "name_suffix": "",
            "institution": "McGill University",
            "department": ""
        }
    ],
    "date_submitted": null,
    "date_accepted": null,
    "date_published": "2019-01-01T18:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "PDF",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/cognitivesciencesociety/article/28419/galley/18290/download/"
        }
    ]
}