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{
    "pk": 41347,
    "title": "Comparative genomics analysis of Liberibacter species to elucidate pathogenesis and culturability",
    "subtitle": null,
    "abstract": "Liberibacter crescens\n BT-1, a gram negative, rod-shaped bacterial isolate, was previously recovered from mountain papaya and sequenced. As L. crescens is culturable and is not a pathogen of citrus, comparative genomics of this strain with other uncultured, pathogenic \nLiberibacter\n should suggest genes involved in both phenotypes. Genomic comparison to \nLiberibacter \nsp\n.\n revealed differences in metabolic pathways and virulence genes.  Specific differences in metabolism include the inability of \nL. asiaticus\n and \nL. solanacearum\n to synthesize histidine, tryptophan, and thiamine, as well as a reduced ability to produce other amino acids. \nL. asiaticus\n and \nL. solanacearum\n possess a thiamine ABC transporter not found in \nL. crescens\n, which may compensate for the inability to synthesize thiamine.  Diversity in the flp pilus operon and metal ABC transporters were observed that may contribute to the pathogenesis of the uncultured species. These differences may contribute to variation in virulence and culturability among species. Finally, two putative prophage regions were found in \nL. crescens\n that share moderate functional similarity to the phage regions of \nL. asiaticus\n, but sequence similarity is not conserved. Additional genomic comparisons will expand our understanding of virulence and vector-interactions of the described\n Liberibacter \nsp.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\n\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [],
    "section": "Abstracts of Presentations at the 3rd International Research Conference on Huanglongbing",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/079419w7",
    "frozenauthors": [
        {
            "first_name": "Michael",
            "middle_name": "T.",
            "last_name": "Leonard",
            "name_suffix": "",
            "institution": "Microbiology and Cell Science Department",
            "department": "None"
        },
        {
            "first_name": "Jennie",
            "middle_name": "R.",
            "last_name": "Fagen",
            "name_suffix": "",
            "institution": "Microbiology and Cell Science Department",
            "department": "None"
        },
        {
            "first_name": "Connor",
            "middle_name": "M.",
            "last_name": "McCullough",
            "name_suffix": "",
            "institution": "Microbiology and Cell Science Department",
            "department": "None"
        },
        {
            "first_name": "Austin",
            "middle_name": "G.",
            "last_name": "Davis-Richardson",
            "name_suffix": "",
            "institution": "Microbiology and Cell Science Department",
            "department": "None"
        },
        {
            "first_name": "Michael",
            "middle_name": "J.",
            "last_name": "Davis",
            "name_suffix": "",
            "institution": "Citrus Research and Education Center;\nPlant Pathology Department, Institute of Food and Agricultural Sciences, University of Florida",
            "department": "None"
        },
        {
            "first_name": "Eric",
            "middle_name": "W.",
            "last_name": "Triplett",
            "name_suffix": "",
            "institution": "Microbiology and Cell Science Department",
            "department": "None"
        }
    ],
    "date_submitted": "2014-12-19T20:39:00-05:00",
    "date_accepted": "2014-12-19T20:39:00-05:00",
    "date_published": "2013-12-31T19:00:00-05:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/iocv_journalcitruspathology/article/41347/galley/30946/download/"
        }
    ]
}