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{
    "pk": 42486,
    "title": "Langerhans Cell Histiocytosis and Erdheim-Chester Disease: A Case Report of Atypical Imaging Overlap",
    "subtitle": null,
    "abstract": "<p>Histiocytoses are rare disorders characterized by abnormal proliferation of histiocytic cells in tissues and organs. They have a broad clinical spectrum and are traditionally categorized as Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (N-LCH), but recent evidence highlights a molecular and clinical overlap between LCH and a type of N-LCH known as Erdheim-Chester disease (ECD). While both disorders have distinct features, up to 20% of ECD patients may present with concurrent LCH lesions. Overlap between LCH and ECD is increasingly recognized, but reports of imaging of this phenomenon are scarce. Here, we present a rare case of directly contiguous LCH and ECD lesions in a 69-year-old woman and discuss the radiologic and histopathologic findings as well as the classification of these findings within the revised histiocytosis system.</p>",
    "language": "eng",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\n\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "Langerhans cell histiocytosis"
        },
        {
            "word": "Erdheim-Chester disease"
        },
        {
            "word": "musculoskeletal radiology"
        },
        {
            "word": "lytic bone lesion"
        },
        {
            "word": "sclerotic bone lesion"
        }
    ],
    "section": "Case Report",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/92q0993g",
    "frozenauthors": [
        {
            "first_name": "Wendy",
            "middle_name": "",
            "last_name": "Qiu",
            "name_suffix": "",
            "institution": "David Geffen School of Medicine at UCLA",
            "department": "Department of Radiological Sciences"
        },
        {
            "first_name": "Zaid",
            "middle_name": "",
            "last_name": "Patel",
            "name_suffix": "",
            "institution": "David Geffen School of Medicine at UCLA; Sutter Health Medical Group, Sacramento, CA",
            "department": "Department of Radiological Sciences"
        },
        {
            "first_name": "Benjamin",
            "middle_name": "",
            "last_name": "Emert",
            "name_suffix": "",
            "institution": "David Geffen School of Medicine at UCLA",
            "department": "Department of Radiological Sciences"
        },
        {
            "first_name": "Varand",
            "middle_name": "",
            "last_name": "Ghazikhanian",
            "name_suffix": "",
            "institution": "David Geffen School of Medicine at UCLA",
            "department": "Department of Radiological Sciences"
        }
    ],
    "date_submitted": "2025-02-09T13:04:47.990000-08:00",
    "date_accepted": "2025-06-06T11:58:06.846000-07:00",
    "date_published": "2025-09-02T18:57:00-07:00",
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        "label": "PDF",
        "type": "pdf",
        "path": "https://journalpub.escholarship.org/ucla_rsp/article/42486/galley/38834/download/"
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}