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{
    "pk": 5673,
    "title": "Sustained Attention in Adult Mice is Modulated by Prenatal Choline Availability",
    "subtitle": null,
    "abstract": "Our laboratory has discovered that alterations in choline availability to the developing rat fetus lead to long-term changes in spatial and temporal memory function across the lifespan and associated changes in the septo-hippocamal system. The current study was undertaken to determine if performance on an attention task, believed to be relatively independent of septo-hippocampal function, was modified by changes in choline availability prior to birth. A sustained attention task was developed for mice that includes all the features of the 2-choice signal-detection procedure initially applied to rats (McGaughy & Sarter, 1995). Prenatal choline deficiency significantly impaired the ability of adult mice to sustain attention to a brief visual cue throughout a session as evidenced by decreased “Hits” and increased “Omissions” during the second-half of trials. In contrast, prenatal choline supplementation enhanced the ability of mice to detect visual cues but did not alter their ability to maintain attention throughout a session. These data support the view that the effects of alterations in choline availability on brain anatomy, physiology, and function likely extend beyond the septo-hippocampal system that modulates spatial memory. In the case of the sustained attention task, this likely includes cholinergic projections from the basal forebrain to neocortex.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "International Journal of Comparative Psychology"
        },
        {
            "word": "Behavior"
        },
        {
            "word": "Behaviour"
        },
        {
            "word": "learning"
        },
        {
            "word": "Behavioral Taxonomy"
        },
        {
            "word": "cognition"
        },
        {
            "word": "Cognitive Processes"
        },
        {
            "word": "attention"
        },
        {
            "word": "MICE"
        },
        {
            "word": "Choline"
        },
        {
            "word": "Spatial memory"
        },
        {
            "word": "Temporal Memory"
        },
        {
            "word": "Septo-Hippocampal System"
        }
    ],
    "section": "Research Article",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/2d4086s1",
    "frozenauthors": [
        {
            "first_name": "Eric G.",
            "middle_name": "",
            "last_name": "Mohler",
            "name_suffix": "",
            "institution": "Duke University, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "Warren H.",
            "middle_name": "",
            "last_name": "Meck",
            "name_suffix": "",
            "institution": "Duke University, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "Christina L.",
            "middle_name": "",
            "last_name": "Williams",
            "name_suffix": "",
            "institution": "Duke University, U.S.A.",
            "department": "None"
        }
    ],
    "date_submitted": "2009-05-05T07:00:00Z",
    "date_accepted": "2009-05-05T07:00:00Z",
    "date_published": "2001-12-31T08:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uclapsych_ijcp/article/5673/galley/3428/download/"
        }
    ]
}