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{
    "pk": 5674,
    "title": "Normal Spatial Learning and Improved Spatial Working Memory in Mice (\nMus musculus\n) Lacking Dopamine D4 Receptors",
    "subtitle": null,
    "abstract": "Dopamine terminals in the hippocampus and prefrontal cortex modulate cognitive processes such as spatial learning and working memory. Because dopamine D4 receptors are expressed in these brain areas we have analyzed mutant mice lacking this receptor subtype (D\nrd4\n-/-). Wild-type and D\nrd4\n-/- mice were challenged in two spatial learning paradigms: the Morris water maze and an alternation T-maze. D\nrd4\n-/- mice showed normal place learning ability to find a hidden platform based on spatial extra-maze cues. In addition, \nDrd4\n-/- mice were able to find a new platform location with the same learning plasticity as wild type-mice. Spatial working memory assessed on a T maze showed that \nDrd4\n-/- mice were more efficient than wild-type mice in acquiring the maximum plateau of correct alternation scores. These results provide further evidence that the functional consequence of lacking D4 receptors is more evident in behaviors dependent on the integrity of the prefrontal cortex.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "International Journal of Comparative Psychology"
        },
        {
            "word": "Behavior"
        },
        {
            "word": "Behaviour"
        },
        {
            "word": "learning"
        },
        {
            "word": "Behavioral Taxonomy"
        },
        {
            "word": "cognition"
        },
        {
            "word": "Cognitive Processes"
        },
        {
            "word": "spatial learning"
        },
        {
            "word": "working memory"
        },
        {
            "word": "dopamine"
        },
        {
            "word": "hippocampus"
        },
        {
            "word": "Prefrontal Cortex"
        },
        {
            "word": "MICE"
        }
    ],
    "section": "Research Article",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/4197x14n",
    "frozenauthors": [
        {
            "first_name": "Tomás L.",
            "middle_name": "",
            "last_name": "Falzone",
            "name_suffix": "",
            "institution": "Instituto de Investigaciones en Ingeniería Genética y Biología Molecular and Universidad de Buenos Aires, Argentina",
            "department": "None"
        },
        {
            "first_name": "Elena M.",
            "middle_name": "",
            "last_name": "Avale",
            "name_suffix": "",
            "institution": "Instituto de Investigaciones en Ingeniería Genética y Biología Molecular and Universidad de Buenos Aires, Argentina",
            "department": "None"
        },
        {
            "first_name": "Diego M.",
            "middle_name": "",
            "last_name": "Gelman",
            "name_suffix": "",
            "institution": "Instituto de Investigaciones en Ingeniería Genética y Biología Molecular and Universidad de Buenos Aires, Argentina",
            "department": "None"
        },
        {
            "first_name": "Marcelo",
            "middle_name": "",
            "last_name": "Rubinstein",
            "name_suffix": "",
            "institution": "Instituto de Investigaciones en Ingeniería Genética y Biología Molecular and Universidad de Buenos Aires, Argentina",
            "department": "None"
        }
    ],
    "date_submitted": "2009-05-05T07:00:00Z",
    "date_accepted": "2009-05-05T07:00:00Z",
    "date_published": "2001-12-31T08:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uclapsych_ijcp/article/5674/galley/3429/download/"
        }
    ]
}