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{
    "pk": 5769,
    "title": "Lesions of the Ventral Tegmental Area Disrupt Drug-induced Appetite Stimulating Effects but Spare Reward Comparison",
    "subtitle": null,
    "abstract": "Dopamine neurons in the ventral tegmental area (VTA) - nucleus accumbens (NAC) pathway track both absolute and relative properties of reward. The present study used 6-hydroxydopamine lesions of the VTA to test the obligate role of this nucleus in morphine- and cocaine-induced suppression of conditioned stimulus (CS) intake and in chlordiazepoxide- and morphine-induced appetite stimulating effects. The results showed that an 80% reduction in accumbens DA fully prevented drug-induced appetite stimulating effects, augmented a latent inhibition-like effect, but failed to disrupt druginduced suppression of CS intake. These data demonstrate that, while the VTA is essential for responding to the reward-enhancing effects of chlordiazepoxide and morphine, it does not contribute to cocaine- or morphine-induced devaluation of the lesser saccharin reward cue.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "International Journal of Comparative Psychology"
        },
        {
            "word": "Behavior"
        },
        {
            "word": "Behaviour"
        },
        {
            "word": "learning"
        },
        {
            "word": "Behavioral Taxonomy"
        },
        {
            "word": "cognition"
        },
        {
            "word": "Cognitive Processes"
        },
        {
            "word": "Emotion"
        },
        {
            "word": "Lesion"
        },
        {
            "word": "Ventral Tegmental Area"
        },
        {
            "word": "dopamine"
        },
        {
            "word": "reward comparison"
        },
        {
            "word": "Nucleus Accumbens"
        },
        {
            "word": "Reward"
        },
        {
            "word": "Saccharin"
        }
    ],
    "section": "Research Article",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/5jp6s30r",
    "frozenauthors": [
        {
            "first_name": "Robert C.",
            "middle_name": "",
            "last_name": "Twining",
            "name_suffix": "",
            "institution": "Penn State University College of Medicine, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "Andras",
            "middle_name": "",
            "last_name": "Hajnal",
            "name_suffix": "",
            "institution": "Penn State University College of Medicine, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "Li",
            "middle_name": "",
            "last_name": "Han",
            "name_suffix": "",
            "institution": "Penn State University College of Medicine, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "Kristy",
            "middle_name": "",
            "last_name": "Bruno",
            "name_suffix": "",
            "institution": "Johns Hopkins University School of Medicine, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "Ellen J.",
            "middle_name": "",
            "last_name": "Hess",
            "name_suffix": "",
            "institution": "Johns Hopkins University School of Medicine, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "Patricia S.",
            "middle_name": "",
            "last_name": "Grigson",
            "name_suffix": "",
            "institution": "Penn State University College of Medicine, U.S.A.",
            "department": "None"
        }
    ],
    "date_submitted": "2009-04-30T03:00:00-04:00",
    "date_accepted": "2009-04-30T03:00:00-04:00",
    "date_published": "2005-12-31T03:00:00-05:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uclapsych_ijcp/article/5769/galley/3524/download/"
        }
    ]
}