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{
    "pk": 5770,
    "title": "The Molecular and Developmental Basis of the Evolution of the Vertebrate Auditory System",
    "subtitle": null,
    "abstract": "We review the molecular basis of the auditory system development and evolution. The auditory periphery evolved by building on the capacity of vestibular hair cells to respond to higher frequency mechanical stimulation. Evolution altered accessory structures to transform vestibular to auditory receptors. Auditory neurons are derived from vestibular neurons, possibly through the expression of the zinc finger protein GATA3. The bHLH gene \nNeurogenin1\n is expressed in the area of the developing vestibular nuclei whereas the bHLH gene \nAtoh1\n is expressed in the developing auditory nuclei. \nAtoh1\n null mice show an almost complete loss of cochlear nuclei. Overall, the ear, sensory neurons and brainstem auditory nuclei show molecular conservation embedded in an organ-specific molecular context. This results in the modification of the developmental pathways governed by these conserved molecules. These data are consistent with the emerging insight that morphological evolution is primarily driven by the modification of gene expression regulation.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "International Journal of Comparative Psychology"
        },
        {
            "word": "Behavior"
        },
        {
            "word": "Behaviour"
        },
        {
            "word": "learning"
        },
        {
            "word": "Behavioral Taxonomy"
        },
        {
            "word": "Morphological Evolution"
        },
        {
            "word": "gene expression"
        },
        {
            "word": "evolution"
        },
        {
            "word": "Vertebrate, Auditory System"
        },
        {
            "word": "Molecular"
        },
        {
            "word": "Developmental"
        }
    ],
    "section": "Research Article",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/0288b9qh",
    "frozenauthors": [
        {
            "first_name": "B.",
            "middle_name": "",
            "last_name": "Fritzsch",
            "name_suffix": "",
            "institution": "Creighton University, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "S.",
            "middle_name": "",
            "last_name": "Pauley",
            "name_suffix": "",
            "institution": "Creighton University, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "F.",
            "middle_name": "",
            "last_name": "Feng",
            "name_suffix": "",
            "institution": "Creighton University, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "V.",
            "middle_name": "",
            "last_name": "Matei",
            "name_suffix": "",
            "institution": "Creighton University, U.S.A.",
            "department": "None"
        },
        {
            "first_name": "D.",
            "middle_name": "H.",
            "last_name": "Nichols",
            "name_suffix": "",
            "institution": "Creighton University, U.S.A.",
            "department": "None"
        }
    ],
    "date_submitted": "2009-04-30T00:00:00-07:00",
    "date_accepted": "2009-04-30T00:00:00-07:00",
    "date_published": "2006-12-31T00:00:00-08:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uclapsych_ijcp/article/5770/galley/3525/download/"
        }
    ]
}