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{
    "pk": 5806,
    "title": "From Classic Aspects of the Stress Response to Neuroinflammation and Sickness: Implications for Individuals and Offspring",
    "subtitle": null,
    "abstract": "Accumulating evidence suggests that exposure to psychological stressors leads to increased expression of pro-inflammatory cytokines and activation of inflammatory-related pathways in the central nervous system. Several logical predictions arise from these findings: (1) stressor exposure should produce changes in behavior that are reminiscent of acute illness; (2) administration of antiinflammatory agents should ameliorate some behavioral consequences of stressor exposure; and (3) there should be convergence between anatomical and neurochemical pathways activated by stressor exposure and those involved in mitigating sickness behaviors. Importantly, these predictions have been tested in our laboratory across multiple stressor paradigms (footshock, maternal separation, and during acute alcohol withdrawal) using two species (rats and guinea pigs), suggesting that sickness may represent a more general motivational state that can be elicited by a diverse range of psychological challenges. Implications of these findings for understanding stress-related changes in behavior, mood and neuroinflammatory processes will be discussed with special reference to implications for the individual and reproductive fitness.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "International Journal of Comparative Psychology"
        },
        {
            "word": "Behavior"
        },
        {
            "word": "Behaviour"
        },
        {
            "word": "learning"
        },
        {
            "word": "Behavioral Taxonomy"
        },
        {
            "word": "cognition"
        },
        {
            "word": "Cognitive Processes"
        },
        {
            "word": "stress response"
        },
        {
            "word": "Physiological"
        },
        {
            "word": "Stressor"
        },
        {
            "word": "Neuroinflammation"
        },
        {
            "word": "Sickness"
        },
        {
            "word": "Antiinflammatory"
        },
        {
            "word": "Rat"
        },
        {
            "word": "Guinea Pig"
        }
    ],
    "section": "Research Article",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/6549c9s1",
    "frozenauthors": [
        {
            "first_name": "Terrence",
            "middle_name": "",
            "last_name": "Deak",
            "name_suffix": "",
            "institution": "State University of New York at Binghamton, U.S.A.",
            "department": "None"
        }
    ],
    "date_submitted": "2009-04-29T07:00:00Z",
    "date_accepted": "2009-04-29T07:00:00Z",
    "date_published": "2007-12-31T08:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uclapsych_ijcp/article/5806/galley/3561/download/"
        }
    ]
}