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{
    "pk": 65130,
    "title": "Evaluation of Irinotecan as a Third- or Fourth-line Treatment for Advanced Non-small Cell Lung Cancer",
    "subtitle": null,
    "abstract": "Lung cancer is the leading cause of cancer-related deaths in the United States. There are two major types of lung cancer: non-small cell lung cancer (NSCLC), which comprises approximately 85% of all lung cancers, and small cell lung cancer. Currently, the most prevalent third- and fourth- line treatment for non-small cell lung cancer is cisplatin-based therapy. This form of therapy has been long established as the chief treatment for advanced NSCLC; however, cisplatin-based therapy also impairs the replication of beneficial cells. Furthermore, insufficient research has been conducted regarding alternative third- and fourth-line treatments. We plan to test the efficacy of irinotecan, a drug that inhibits nuclear enzymes associated with DNA replication and transcription, as a third- or fourth-line treatment for advanced NSCLC in a phase III study. Irinotecan could provide NSCLC patients with an alternative treatment with lower risk of excessive toxicity. Furthermore, this study would supply the foundation for future research concerning later-line treatments for advanced NSCLC.",
    "language": "en",
    "license": null,
    "keywords": [
        {
            "word": "Evaluation"
        },
        {
            "word": "Irinotecan"
        },
        {
            "word": "treatment"
        },
        {
            "word": "advanced"
        },
        {
            "word": "non-small cell lung cancer"
        }
    ],
    "section": "Articles",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/0nh7m2pg",
    "frozenauthors": [
        {
            "first_name": "James",
            "middle_name": "",
            "last_name": "Keener",
            "name_suffix": "",
            "institution": "",
            "department": ""
        }
    ],
    "date_submitted": "2013-12-20T08:29:39Z",
    "date_accepted": "2013-12-20T08:29:39Z",
    "date_published": "2013-12-20T08:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/ucm_mwp_ucmurj/article/65130/galley/49898/download/"
        }
    ]
}