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{
    "pk": 65598,
    "title": "Evolving Resistance: How Natural Selection Evolved Cancer Suppression Across Species and Within Organisms",
    "subtitle": null,
    "abstract": "Cancer is frequently regarded as a modern illness; however, its origins are intertwined with the evolutionary background of multicellular organisms. The persistence of cancer reflects a fundamental evolutionary challenge: how organisms maintain cooperation among billions of cells while preventing the rise of selfish, malignant ones. In this review paper, we will examine how natural selection influences the development of cancer suppression mechanisms within individual organisms and across various species. We will concentrate on two key areas: first, the Darwinian characteristics of cancer as a clonal evolutionary process driven by mutation, competition, and selection within the body; and second, the evolution of the immune and genetic defense system that inhibits tumor formation to a limit. The development of somatic defenses that have delayed cancer’s progression in long-lived species usually entails trade-offs such as aging, diminished regenerative abilities, and reduced reproductive capacity. We will also mention comparative studies that show that species such as naked mole rats, elephants, and whales have independently evolved distinct anti-cancer mechanisms, illustrating the varied approaches to a shared issue. Considering cancer from an evolutionary perspective can broaden understandings of its original traces and endurance. It also provides valuable insight into how organisms balance longevity and cellular integrity. Ultimately, integrating evolutionary theory with oncology may guide the development of more adaptive therapies and preventive approaches inspired by nature’s own long-term solutions.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution-NonCommercial  4.0",
        "short_name": "CC BY-NC 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\n\nNonCommercial — You may not use the material for commercial purposes.\n\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by-nc/4.0"
    },
    "keywords": [],
    "section": "Articles",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/4934p5b2",
    "frozenauthors": [
        {
            "first_name": "Loura",
            "middle_name": "",
            "last_name": "Welson",
            "name_suffix": "",
            "institution": "",
            "department": ""
        }
    ],
    "date_submitted": "2025-12-16T20:25:59Z",
    "date_accepted": "2025-12-16T20:25:59Z",
    "date_published": "2025-01-01T00:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/ucm_mwp_ucmurj/article/65598/galley/50227/download/"
        }
    ]
}