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{
    "pk": 683,
    "title": "Left Ventricular Regional Wall Motion Abnormality in the Setting of Acute Loperamide Overdose",
    "subtitle": null,
    "abstract": "Loperamide is an inexpensive, over-the-counter antidiarrheal agent with emerging reports of overdose due to its opioid properties. Although it is considered by many patients to be safe, cardiotoxicity has been reported, prompting the United States Food and Drug Administration to release a warning regarding the arrhythmogenic potential of loperamide. We present a case of a 32-year-old male presenting in acute loperamide overdose and subsequent cardiac dysrhythmia with focal wall motion abnormalities on echocardiogram. This finding has not been previously reported in the literature and is unique in this clinical presentation. We also highlight the potential mechanisms for loperamide cardiotoxicity and its challenging management.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [],
    "section": "Case Reports",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/9hm8j0jn",
    "frozenauthors": [
        {
            "first_name": "Kasha",
            "middle_name": "",
            "last_name": "Bornstein",
            "name_suffix": "",
            "institution": "University of Miami Miller School of Medicine, Miami, Florida",
            "department": "None"
        },
        {
            "first_name": "Timonthy",
            "middle_name": "",
            "last_name": "Montrief",
            "name_suffix": "",
            "institution": "Jackson Memorial Hospital, Department of Emergency Medicine, Miami, Florida",
            "department": "None"
        },
        {
            "first_name": "Mehruba",
            "middle_name": "",
            "last_name": "Anwar Parris",
            "name_suffix": "",
            "institution": "Jackson Memorial Hospital, Department of Emergency Medicine, Miami, Florida",
            "department": "None"
        }
    ],
    "date_submitted": "2019-05-20T23:44:58+01:00",
    "date_accepted": "2019-05-20T23:44:58+01:00",
    "date_published": "2019-07-01T22:25:55+01:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uciem_cpcem/article/683/galley/442/download/"
        }
    ]
}