Article Instance

HTTP 200 OK
Allow: GET
Content-Type: application/json
Vary: Accept

{
    "pk": 7593,
    "title": "Onset and Duration of Intravenous and Intraosseous Rocuronium in Swine",
    "subtitle": null,
    "abstract": "Introduction: The intraosseous (IO) route has become a popular method to gain access to the peripheral circulation in emergency situations. Despite little supporting data, it is generally believed that IO absorption is immediate and equivalent to the intravenous (IV) route. It is important to determine if rocuronium can effectively be administered by the IO route. The aim of the study was to determine and compare the onset and duration of rocuronium when administered via the IO and IV routes in a normovolemic pig model.\nMethods: We recorded electromyographic (EMG) data following tibial IO and peripheral IV administration of rocuronium (1.2 mg/kg) in 10 swine weighing between 56 and 71 Kg. We transformed data were transformed to percent of baseline, determined onset and recovery characteristics.\nResults: The onset EMG-time profiles for IO and IV administration were very similar: tibial IO compared to IV administration did not statistically alter the onset of paralysis. The IO group took statistically longer than the IV group to return to 50 (p=0.042), 75 (p=0.034) and 95 (p=0.036) percent of baseline activity.\nConclusion: The duration of effect is statistically longer after IO administration but is more of an academic interest than a clinical concern. The results of this study suggest that rocuronium can effectively be administered via the IO route without the need for dose adjustments. [West J Emerg Med. 2014;15(2):241-245.]",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution-NonCommercial  4.0",
        "short_name": "CC BY-NC 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNonCommercial — You may not use the material for commercial purposes.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by-nc/4.0"
    },
    "keywords": [
        {
            "word": "Intraosseous"
        },
        {
            "word": "pharmacokinetics"
        },
        {
            "word": "Emergency Medicine"
        },
        {
            "word": "anesthesia"
        }
    ],
    "section": "Injury Outcomes",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/8n3682pf",
    "frozenauthors": [
        {
            "first_name": "Michael",
            "middle_name": "J",
            "last_name": "Loughren",
            "name_suffix": "",
            "institution": "Department of Anesthesia & Operative Services, Madigan Army Medical Center, Tacoma, Washington",
            "department": "None"
        },
        {
            "first_name": "Sarah",
            "middle_name": "",
            "last_name": "Banks",
            "name_suffix": "",
            "institution": "Department of Anesthesia & Operative Services, Madigan Army Medical Center, Tacoma, Washington",
            "department": "None"
        },
        {
            "first_name": "Carleo",
            "middle_name": "",
            "last_name": "Naluan",
            "name_suffix": "",
            "institution": "Department of Anesthesia & Operative Services, Madigan Army Medical Center, Tacoma, Washington",
            "department": "None"
        },
        {
            "first_name": "Paul",
            "middle_name": "",
            "last_name": "Portenlanger",
            "name_suffix": "",
            "institution": "Department of Anesthesia & Operative Services, Madigan Army Medical Center, Tacoma, Washington",
            "department": "None"
        },
        {
            "first_name": "Arthur",
            "middle_name": "",
            "last_name": "Wendorf",
            "name_suffix": "",
            "institution": "Department of Anesthesia & Operative Services, Madigan Army Medical Center, Tacoma, Washington",
            "department": "None"
        },
        {
            "first_name": "Don",
            "middle_name": "",
            "last_name": "Johnson",
            "name_suffix": "",
            "institution": "Department of Anesthesia & Operative Services, Madigan Army Medical Center, Tacoma, Washington",
            "department": "None"
        }
    ],
    "date_submitted": "2012-10-31T04:54:13Z",
    "date_accepted": "2012-10-31T04:54:13Z",
    "date_published": "2014-01-10T08:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/7593/galley/4458/download/"
        }
    ]
}