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{ "pk": 8724, "title": "Physician Documentation of Sepsis Syndrome Is Associated with More Aggressive Treatment", "subtitle": null, "abstract": "Introduction: \nTimely recognition and treatment of sepsis improves survival. The objective is to examine the association between recognition of sepsis and timeliness of treatments.\nMethods: \nWe identified a retrospective cohort of emergency department (ED) patients with positive blood cultures from May 2007 to January 2009, and reviewed vital signs, imaging, laboratory data, and physician/nursing charts. Patients who met systemic inflammatory response syndrome (SIRS) criteria and had evidence of infection available to the treating clinician at the time of the encounter were classified as having sepsis. Patients were dichotomized as RECOGNIZED if sepsis was explicitly articulated in the patient record or if a sepsis order set was launched, or as UNRECOGNIZED if neither of these two criteria were met. We used median regression to compare time to antibiotic administration and total volume of fluid resuscitation between groups, controlling for age, sex, and sepsis severity.\nResults: \nSIRS criteria were present in 228/315 (72.4%) cases. Our record review identified sepsis syndromes in 214 (67.9%) cases of which 118 (55.1%) had sepsis, 64 (29.9%) had severe sepsis, and 32 (15.0%) had septic shock. The treating team contemplated sepsis (RECOGNIZED) in 123 (57.6%) patients. Compared to the UNRECOGNIZED group, the RECOGNIZED group had a higher use of antibiotics in the ED (91.9 vs.75.8%, p=0.002), more patients aged 60 years or older (56.9 vs. 33.0%, p=0.001), and more severe cases (septic shock: 18.7 vs. 9.9%, severe sepsis: 39.0 vs.17.6%, sepsis: 42.3 vs.72.5%; p<0.001). The median time to antibiotic (minutes) was lower in the RECOGNIZED (142) versus UNRECOGNIZED (229) group, with an adjusted median difference of -74 minutes (95% CI [-128 to -19]). The median total volume of fluid resuscitation (mL) was higher in the RECOGNIZED (1,600 mL) compared to the UNRECOGNIZED (1,000 mL) group. However, the adjusted median difference was not statistically significant: 262 mL (95% CI [ -171 to 694 mL]).\nConclusion: \nPatients whose emergency physicians articulated sepsis syndrome in their documentation or who launched the sepsis order set received antibiotics sooner and received more total volume of fluid. Age <60 and absence of fever are factors associated with lack of recognition of sepsis cases. [West J Emerg Med. 2015;16(3):401–407.]", "language": "en", "license": { "name": "Creative Commons Attribution 4.0", "short_name": "CC BY 4.0", "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.", "url": "https://creativecommons.org/licenses/by/4.0" }, "keywords": [ { "word": "Sepsis, Emergency Department, Documentation, Differential Diagnosis" } ], "section": "Health Outcomes", "is_remote": true, "remote_url": "https://escholarship.org/uc/item/1bj4v73h", "frozenauthors": [ { "first_name": "Lisa", "middle_name": "R.", "last_name": "Stoneking", "name_suffix": "", "institution": "The University of Arizona College of Medicine, Department of Emergency Medicine, Tucson, Arizona", "department": "None" }, { "first_name": "John", "middle_name": "P.", "last_name": "Winkler", "name_suffix": "", "institution": "The University of Arizona College of Medicine, Department of Emergency Medicine, Tucson, Arizona", "department": "None" }, { "first_name": "Lawrence", "middle_name": "A.", "last_name": "DeLuca", "name_suffix": "", "institution": "The University of Arizona College of Medicine, Department of Emergency Medicine, Tucson, Arizona", "department": "None" }, { "first_name": "Uwe", "middle_name": "", "last_name": "Stolz", "name_suffix": "", "institution": "The University of Arizona College of Medicine, Department of Emergency Medicine, Tucson, Arizona", "department": "None" }, { "first_name": "Aaron", "middle_name": "", "last_name": "Stutz", "name_suffix": "", "institution": "Fairchild Medical Center, Yreka, California", "department": "None" }, { "first_name": "Jenifer", "middle_name": "C.", "last_name": "Luman", "name_suffix": "", "institution": "EMA, Alvarado Hospital Emergency Department, San Diego, California; Scripps Encinitas Emergency Department, Encinitas, California", "department": "None" }, { "first_name": "Michael", "middle_name": "", "last_name": "Gaub", "name_suffix": "", "institution": "The University of Arizona College of Medicine, Department of Emergency Medicine, Tucson, Arizona", "department": "None" }, { "first_name": "Donna", "middle_name": "M.", "last_name": "Wolk", "name_suffix": "", "institution": "Geisinger Health System, Department of Laboratory Medicine, Danville, Pennsylvania", "department": "None" }, { "first_name": "Albert", "middle_name": "B.", "last_name": "Fiorello", "name_suffix": "", "institution": "The University of Arizona College of Medicine, Department of Emergency Medicine, Tucson, Arizona", "department": "None" }, { "first_name": "Kurt", "middle_name": "R.", "last_name": "Denninghoff", "name_suffix": "", "institution": "The University of Arizona College of Medicine, Department of Emergency Medicine, Tucson, Arizona", "department": "None" } ], "date_submitted": "2015-01-25T19:26:12Z", "date_accepted": "2015-01-25T19:26:12Z", "date_published": "2015-04-10T17:55:32Z", "render_galley": null, "galleys": [ { "label": "", "type": "pdf", "path": "https://journalpub.escholarship.org/westjem/article/8724/galley/5005/download/" } ] }