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{
    "pk": 928,
    "title": "Inhaled Tranexamic Acid for Massive Hemoptysis in the Setting of Oral Anticoagulation: A Case Report",
    "subtitle": null,
    "abstract": "Introduction:\n We discuss a case of massive hemoptysis in the setting of a direct-acting oral anticoagulant (DOAC) successfully managed with nebulized tranexamic acid (TXA).\nCase Report:\n Per the American College of Cardiology and the American Society of Hematology, it is recommended that significant bleeding associated with a DOAC be treated with either 4-factor prothrombin complex concentrate or andexanet alfa. However, our patient was at high risk for thrombotic complications given a recent pulmonary embolism.\nConclusion:\n We demonstrate that it is reasonable to trial nebulized TXA given its low cost, ease of administration, and safety profile. Additionally, this report discusses a unique dosing strategy and a previously unreported complication associated with nebulization of undiluted TXA.",
    "language": "en",
    "license": {
        "name": "Creative Commons Attribution 4.0",
        "short_name": "CC BY 4.0",
        "text": "Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.\r\n\r\nNo additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.",
        "url": "https://creativecommons.org/licenses/by/4.0"
    },
    "keywords": [
        {
            "word": "rivaroxaban"
        },
        {
            "word": "hemoptysis"
        },
        {
            "word": "tranexamic acid"
        }
    ],
    "section": "Case Reports",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/12n4q5j4",
    "frozenauthors": [
        {
            "first_name": "Jacqueline",
            "middle_name": "M.",
            "last_name": "Dempsey",
            "name_suffix": "",
            "institution": "University of Kentucky HealthCare, Department of Pharmacy Services, Lexington, Kentucky",
            "department": "None"
        },
        {
            "first_name": "Mandy",
            "middle_name": "",
            "last_name": "Jones",
            "name_suffix": "",
            "institution": "University of Kentucky, Department of Pharmacy Practice and Science, Lexington, Kentucky",
            "department": "None"
        },
        {
            "first_name": "Jonathan",
            "middle_name": "",
            "last_name": "Bronner",
            "name_suffix": "",
            "institution": "University of Kentucky HealthCare, Department of Emergency Medicine, Lexington, Kentucky",
            "department": "None"
        },
        {
            "first_name": "Connor",
            "middle_name": "",
            "last_name": "Greer",
            "name_suffix": "",
            "institution": "University of Kentucky HealthCare, Department of Emergency Medicine, Lexington, Kentucky",
            "department": "None"
        },
        {
            "first_name": "Gavin",
            "middle_name": "T.",
            "last_name": "Howington",
            "name_suffix": "",
            "institution": "University of Kentucky HealthCare, Department of Pharmacy Services, Lexington, Kentucky; University of Kentucky, Department of Pharmacy Practice and Science, Lexington, Kentucky",
            "department": "None"
        }
    ],
    "date_submitted": "2020-10-06T07:14:08+08:00",
    "date_accepted": "2020-10-06T07:14:08+08:00",
    "date_published": "2020-10-06T07:15:12+08:00",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "",
            "path": "https://journalpub.escholarship.org/uciem_cpcem/article/928/galley/676/download/"
        }
    ]
}