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{
    "pk": 16600,
    "title": "Tinnitus as a Measure of Salicylate Toxicity in the Overdose Setting",
    "subtitle": null,
    "abstract": "Introduction: The development of tinnitus and/or hearing loss (THL) in patients receiving chronic salicylate therapy has been demonstrated. However, to date, little scientific data validates this relationship in the large single overdose setting.\n\n\nObjective: To correlate salicylate levels in patients with the subjective complaint of THL, following an acute salicylate overdose.\n\n\nMethods: A retrospective chart review of cases of acute salicylate toxicity and THL reported to the Illinois Poison Control Center (IPC) from 2001-2002 was performed. Data abstracted included age, gender, ingestion time, salicylate levels, and arterial blood gases.\n\n\nResults: Ninety-nine cases of THL were reviewed and analyzed with mean age of 23.7 years (SD: 10.9), 30.3% male, and 82.2% intentional overdoses. The average dose ingested was 20.0 grams (SD:20.2) and the mean time from ingestion to medical care was 12.4 hours (SD: 11.1). The mean initial ASA level was 48.3 mg/dl (SD: 16.4) with 86.9% having initial level ≥ 30mg/dl and 40.4% ≥ 50 mg/dl. 85.9% of cases presented to the hospital with their ASA level at or past peak. The mean pH was 7.45, pO2 = 108, pCO2 = 28.0, and HCO3 = 19.9.\n\n\nConclusion: In this limited study, 85.9% of patients presenting with tinnitus and/or hearing loss following a single salicylate ingestion had initial salicylate levels at or past their peak and 86.9% were in the toxic range.\n\n\n[WestJEM. 2008;9:146-149.]",
    "language": "en",
    "license": {
        "name": "none",
        "short_name": "none",
        "text": "",
        "url": "http://google.com"
    },
    "keywords": [
        {
            "word": "Salicylate"
        },
        {
            "word": "Tinnitus"
        },
        {
            "word": "overdose"
        },
        {
            "word": "Salicylate levels"
        }
    ],
    "section": "Article",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/01j749kg",
    "frozenauthors": [
        {
            "first_name": "Scott",
            "middle_name": "R",
            "last_name": "Samlan",
            "name_suffix": "",
            "institution": "Emergency Medicine Residency Program, Resurrection Medical Center, Chicago, Illinois",
            "department": "None"
        },
        {
            "first_name": "Matthew",
            "middle_name": "T",
            "last_name": "Jordan",
            "name_suffix": "",
            "institution": "Emergency Medicine Residency Program, Resurrection Medical Center, Chicago, Illinois",
            "department": "None"
        },
        {
            "first_name": "Shu",
            "middle_name": "B.",
            "last_name": "Chan",
            "name_suffix": "",
            "institution": "Emergency Medicine Residency Program, Resurrection Medical Center",
            "department": "None"
        },
        {
            "first_name": "Michael",
            "middle_name": "S",
            "last_name": "Wahl",
            "name_suffix": "",
            "institution": "Evanston Northwestern Healthcare, Illinois Poison Center, Chicago & Evanston, Illinois",
            "department": "None"
        },
        {
            "first_name": "Rachel",
            "middle_name": "L",
            "last_name": "Rubin",
            "name_suffix": "",
            "institution": "Emergency Medicine Residency Program, Resurrection Medical Center",
            "department": "None"
        }
    ],
    "date_submitted": "2007-11-20T08:00:00Z",
    "date_accepted": "2007-11-20T08:00:00Z",
    "date_published": "2008-06-23T07:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/westjem/article/16600/galley/8397/download/"
        }
    ]
}