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{
    "pk": 25662,
    "title": "Influence of Excitation/Inhibition Imbalance on Local Processing Bias in\nAutism Spectrum Disorder",
    "subtitle": null,
    "abstract": "People with autism spectrum disorder (ASD) tend to detect lo-\ncal patterns of visual stimuli more quickly than global patterns,\nwhich is opposite to the behavior of typically developing peo-\nple. We hypothesized that the imbalance between excitation\nand inhibition neurons in the visual cortex causes the local pro-\ncessing bias observed in ASD. Stronger inhibitory connections\ncould diminish the neural activities and thus prevent global fea-\nture integration, whereas properly balanced connections would\nenable the cortex to detect features of any size. We verified\nour hypothesis by employing a computational neural network\ncalled a neocognitron. Our experimental results demonstrated\nthat the network with stronger inhibitory connections exhib-\nited a local processing bias, whereas the network with properly\nadjusted connections showed a moderate global bias. More-\nover, the networks with extremely strong or weak inhibitions\nrevealed no perception bias. These results suggest that an ex-\ncitation/inhibition imbalance causes multiple types of atypical\nperception in ASD.",
    "language": "eng",
    "license": {
        "name": "",
        "short_name": "",
        "text": null,
        "url": ""
    },
    "keywords": [
        {
            "word": "autism spectrum disorder; local processing bias;\nexcitation/inhibition balance; neocognitron"
        }
    ],
    "section": "Papers",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/0tj1p2gb",
    "frozenauthors": [
        {
            "first_name": "Yukie",
            "middle_name": "",
            "last_name": "Nagai",
            "name_suffix": "",
            "institution": "Osaka University",
            "department": ""
        },
        {
            "first_name": "Takakazu",
            "middle_name": "",
            "last_name": "Moriwaki",
            "name_suffix": "",
            "institution": "Osaka University",
            "department": ""
        },
        {
            "first_name": "Minoru",
            "middle_name": "",
            "last_name": "Asada",
            "name_suffix": "",
            "institution": "Osaka University",
            "department": ""
        }
    ],
    "date_submitted": null,
    "date_accepted": null,
    "date_published": "2015-01-01T18:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "PDF",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/cognitivesciencesociety/article/25662/galley/15286/download/"
        }
    ]
}