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{
    "pk": 26848,
    "title": "A Cognitive-Pharmacokinetic Computational Model of the Effect of Toluene onPerformance",
    "subtitle": null,
    "abstract": "We developed a cognitive-pharmacokinetic computational(CPC) model to understand how pharmacoactive substances,such as caffeine and toluene, modulate cognition. In this in-tegrated model, dynamic physiological mechanisms are sim-ulated to predict concentrations of the solvent toluene in thebrain, which modulates specific cognitive systems in a dose-response fashion over multiple hours. We used our CPC modelto reanalyze the results from prior research that documented anincrease in reaction time following exposure to toluene in sev-eral laboratory tasks with no change in accuracy. Our analysisprovides tentative evidence that toluene affects motor execu-tion, rather than attention or declarative memory.",
    "language": "eng",
    "license": {
        "name": "",
        "short_name": "",
        "text": null,
        "url": ""
    },
    "keywords": [
        {
            "word": "ACT-R; Toluene; Pharmacokinetic; Computa-tional Models"
        }
    ],
    "section": "Talks: Papers",
    "is_remote": true,
    "remote_url": "https://escholarship.org/uc/item/1mh7619k",
    "frozenauthors": [
        {
            "first_name": "Christopher",
            "middle_name": "R.",
            "last_name": "Fisher",
            "name_suffix": "",
            "institution": "Air Force Research Laboratory, Wright-Patterson Air Force Base",
            "department": ""
        },
        {
            "first_name": "Christopher",
            "middle_name": "",
            "last_name": "Myers",
            "name_suffix": "",
            "institution": "Air Force Research Laboratory, Wright-Patterson Air Force Base",
            "department": ""
        },
        {
            "first_name": "Reem",
            "middle_name": "",
            "last_name": "Hassan",
            "name_suffix": "",
            "institution": "Air Force Research Laboratory, Wright-Patterson Air Force Base",
            "department": ""
        },
        {
            "first_name": "Christopher",
            "middle_name": "",
            "last_name": "Stevens",
            "name_suffix": "",
            "institution": "Air Force Research Laboratory, Wright-Patterson Air Force Base",
            "department": ""
        },
        {
            "first_name": "C. Eric",
            "middle_name": "",
            "last_name": "Hack",
            "name_suffix": "",
            "institution": "Air Force Research Laboratory, Wright-Patterson Air Force Base",
            "department": ""
        },
        {
            "first_name": "Jeffery",
            "middle_name": "",
            "last_name": "Gearhart",
            "name_suffix": "",
            "institution": "Air Force Research Laboratory, Wright-Patterson Air Force Base",
            "department": ""
        },
        {
            "first_name": "Glenn",
            "middle_name": "",
            "last_name": "Gunzelmann",
            "name_suffix": "",
            "institution": "Air Force Research Laboratory, Wright-Patterson Air Force Base",
            "department": ""
        }
    ],
    "date_submitted": null,
    "date_accepted": null,
    "date_published": "2017-01-01T18:00:00Z",
    "render_galley": null,
    "galleys": [
        {
            "label": "PDF",
            "type": "pdf",
            "path": "https://journalpub.escholarship.org/cognitivesciencesociety/article/26848/galley/16484/download/"
        }
    ]
}